| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 12% | $75,677,910 | 8,362,200 | The Vanguard Group | 31 Mar 2025 | |||
| BlackRock, Inc. | 7.9% | $49,076,304 | 5,422,796 | BlackRock, Inc. | 31 Mar 2025 | |||
| D. E. SHAW & CO, L.P. | 5.3% | $29,010,822 | 3,405,026 | D. E. Shaw & Co., L.P. | 06 Nov 2025 | |||
| Logos Global Management LP | 3.4% | -58% | $21,300,000 | -$32,376,000 | 2,500,000 | -60% | Logos Global Management LP | 13 Oct 2025 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.9% | $10,605,117 | 1,333,977 | T. Rowe Price Associates, Inc. | 30 Jun 2025 | |||
| CITADEL ADVISORS LLC | 0.4% | -94% | $2,251,350 | -$27,399,315 | 264,243 | -92% | Kenneth Griffin | 30 Sep 2025 |
| Filer | Ownership | Nb Shares | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | 13% | 8,561,232 | -8.9% | 0% | $72,941,695 |
| BlackRock, Inc. | 11% | 6,802,938 | -1.3% | 0% | $57,961,031 |
| Logos Global Management LP | 8.7% | 5,575,000 | +69% | 4.7% | $47,499,000 |
| Pfizer Inc | 5.4% | 3,457,815 | 0% | 6.7% | $29,460,584 |
| D. E. Shaw & Co., Inc. | 5.2% | 3,347,163 | +56% | 0.02% | $28,517,828 |
| MILLENNIUM MANAGEMENT LLC | 3.3% | 2,131,555 | +12% | 0.01% | $18,160,849 |
| STATE STREET CORP | 2.9% | 1,873,086 | +8.1% | 0% | $15,958,693 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.6% | 1,670,179 | +5.4% | 0% | $14,232,270 |
| MORGAN STANLEY | 2.6% | 1,662,221 | +5% | 0% | $14,162,126 |
| TCG Crossover Management, LLC | 2.5% | 1,617,365 | 0.68% | $13,779,950 | |
| New Leaf Venture Partners, L.L.C. | 2.5% | 1,585,721 | 0% | 31% | $13,510,343 |
| Qube Research & Technologies Ltd | 2.3% | 1,486,864 | +155% | 0.02% | $12,668,081 |
| ACADIAN ASSET MANAGEMENT LLC | 2.3% | 1,464,413 | +2.6% | 0.02% | $12,470,000 |
| Nextech Invest, Ltd. | 2.2% | 1,408,394 | 0% | 1.8% | $11,999,517 |
| TANG CAPITAL MANAGEMENT LLC | 2.2% | 1,393,800 | 0% | 0.46% | $11,875,176 |
| Balyasny Asset Management L.P. | 1.9% | 1,207,267 | +469% | 0.02% | $10,285,915 |
| ARMISTICE CAPITAL, LLC | 1.9% | 1,200,000 | +114% | 0.32% | $10,224,000 |
| Opaleye Management Inc. | 1.5% | 987,818 | -41% | 1.2% | $8,416,209 |
| GOLDMAN SACHS GROUP INC | 1.1% | 736,563 | -11% | 0% | $6,275,517 |
| Monaco Asset Management SAM | 1.1% | 710,936 | -21% | 2.3% | $6,057,175 |
| Avidity Partners Management LP | 1.1% | 698,363 | +187% | 1.4% | $5,950,053 |
| Rangeley Capital, LLC | 1.1% | 695,400 | +0.09% | 5.7% | $5,924,808 |
| FEDERATED HERMES, INC. | 1.1% | 680,885 | -0.88% | 0.01% | $5,801,140 |
| RENAISSANCE TECHNOLOGIES LLC | 1% | 669,655 | -45% | 0.01% | $5,705,461 |
| DIMENSIONAL FUND ADVISORS LP | 1% | 665,752 | -0.35% | 0% | $5,672,256 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 497,560 | $5,915,927 | -$731,934 | $11.86 | 5 |
| 2025 Q3 | 66,985,753 | $570,685,833 | -$18,347,852 | $8.52 | 206 |
| 2025 Q2 | 69,773,093 | $513,755,861 | +$45,413,542 | $7.36 | 211 |
| 2025 Q1 | 64,043,851 | $449,669,566 | -$319,330,680 | $7.02 | 209 |
| 2024 Q4 | 76,532,832 | $1,469,563,794 | -$40,577,415 | $19.17 | 194 |
| 2024 Q3 | 72,359,317 | $1,782,385,662 | +$27,159,504 | $24.63 | 202 |
| 2024 Q2 | 70,959,691 | $1,888,221,547 | +$43,361,614 | $26.62 | 200 |
| 2024 Q1 | 68,778,996 | $2,837,948,261 | +$167,461,815 | $41.28 | 217 |
| 2023 Q4 | 64,880,659 | $2,669,124,922 | +$685,415,889 | $41.16 | 209 |
| 2023 Q3 | 48,848,509 | $958,997,317 | +$43,305,631 | $19.64 | 153 |
| 2023 Q2 | 46,877,176 | $1,164,404,685 | -$56,956,271 | $24.82 | 153 |
| 2023 Q1 | 49,042,748 | $1,338,695,039 | -$37,288,624 | $27.32 | 169 |
| 2022 Q4 | 50,139,990 | $1,715,213,068 | -$3,095,277 | $34.21 | 159 |
| 2022 Q3 | 49,914,067 | $2,221,103,231 | -$31,447,539 | $44.49 | 170 |
| 2022 Q2 | 49,398,627 | $2,079,588,693 | +$84,067,244 | $42.09 | 165 |
| 2022 Q1 | 46,900,586 | $3,156,123,578 | +$97,508,393 | $67.30 | 171 |
| 2021 Q4 | 44,953,026 | $3,691,561,033 | +$1,619,301 | $82.14 | 192 |
| 2021 Q3 | 44,264,897 | $3,638,609,685 | -$131,317,649 | $82.18 | 198 |
| 2021 Q2 | 45,694,784 | $3,518,436,382 | +$227,593,847 | $77.00 | 175 |
| 2021 Q1 | 43,228,347 | $2,857,205,804 | -$301,748,507 | $66.10 | 174 |
| 2020 Q4 | 46,669,497 | $3,963,432,733 | +$918,823,993 | $84.93 | 184 |
| 2020 Q3 | 36,694,916 | $866,240,095 | -$1,688,225 | $23.61 | 137 |
| 2020 Q2 | 36,363,334 | $1,219,574,175 | +$121,333,383 | $33.54 | 138 |
| 2020 Q1 | 32,321,197 | $1,302,589,429 | +$84,805,141 | $40.30 | 123 |
| 2019 Q4 | 30,167,526 | $1,239,580,627 | +$339,116,518 | $41.09 | 121 |
| 2019 Q3 | 16,126,090 | $347,535,434 | +$17,714,443 | $21.55 | 81 |
| 2019 Q2 | 15,526,242 | $341,427,638 | +$40,980,659 | $21.99 | 66 |
| 2019 Q1 | 13,873,634 | $204,769,867 | +$9,769,894 | $14.76 | 54 |
| 2018 Q4 | 13,267,139 | $170,482,000 | -$16,698,505 | $12.85 | 49 |
| 2018 Q3 | 13,681,030 | $230,794,000 | +$230,794,003 | $16.87 | 40 |