| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Sphera Funds Management Ltd. | 5.51% | 3,122,090 | 0 | 3,122,090 | /s/ Adi Hanetz | Adi Hanetz / General Counsel | |
| Sphera Global Healthcare GP Ltd. | 5.51% | 3,122,090 | 0 | 3,122,090 | /s/ Adi Hanetz | Adi Hanetz / General Counsel | |
| Sphera Global Healthcare Management LP. | 5.51% | 3,122,090 | 0 | 3,122,090 | /s/ Adi Hanetz | Adi Hanetz / General Counsel |