| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| BB Biotech AG | 4.8% | 2.73M | 0 | 2.73M | /s/ Martin Gubler | Martin Gubler/Signatory Authority | |
| Biotech Growth N.V. | 4.8% | 2.73M | 0 | 2.73M | /s/ Jan Bootsma | Jan Bootsma/Signatory Authority |