CMLS Holdings LLC - 22 Aug 2025 SCHEDULE 13D/A Report for GeneDx Holdings Corp. Class A common stock, par value $0.0001 per share (WGS)

Filing Manager: CMLS Holdings LLC
Reporting Manager: Keith A. Meister
Security: GeneDx Holdings Corp. Class A common stock, par value $0.0001 per share
Symbol: WGS
Shares outstanding: 29M shares
Disclosed Ownership: 3.63M shares
Ownership: 12.5%
Form type: SCHEDULE 13D/A
Filing time: 26 Aug 2025, 11:27:12 UTC
Date of event: 22 Aug 2025
Previous filing: 07 May 2025
SEC: View on sec.gov

Reporting Managers (9)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
CMLS Holdings LLC	1.9%	537K	0	537K	By: /s/ Eli Casdin	Eli Casdin, Manager	0001822257
C-LSH LLC	1.9%	537K	0	537K	By: /s/ Eli Casdin	Eli Casdin, Managing Member	0001822233
M-LSH LLC	1.9%	537K	0	537K	By: /s/ Keith A. Meister	Keith A. Meister, Managing Member	0001822736
Casdin Capital, LLC	10.5%	3.01M	0	3.01M	By: /s/ Eli Casdin	Eli Casdin, Managing Member	0001534261
Casdin Partners Master Fund, L.P.	10.5%	3.01M	0	3.01M	By: /s/ Eli Casdin	Eli Casdin, Managing Member of its General Partner	0001534265
Casdin Partners GP, LLC	10.5%	3.03M	0	3.03M	By: /s/ Eli Casdin	Eli Casdin, Managing Member	0001534260
Eli Casdin	12.4%	3.6M	36K	3.56M	By: /s/ Eli Casdin	Eli Casdin	0001534264
Keith A. Meister	12.5%	3.63M	34.9K	3.6M	By: /s/ Keith A. Meister	Keith A. Meister	0001307631
Corvex Management LP	10.6%	3.06M	0	3.06M	By: /s/ Keith A. Meister	Keith Meister, Managing Partner	0001535472