Avidity Partners Management LP - Dec 31, 2024 SCHEDULE 13G/A Report for Syros Pharmaceuticals, Inc. Common Stock, $0.001 par value (SYRS)

Reporting Managers (8)

Name	Ownership	Shares Owned	shared voting power	Signature	Title
Avidity Partners Management LP	7.6%	2.05M	2.05M	By Avidity Partners Management (GP) LLC, its general partner, By: /s/ Michael Gregory	Michael Gregory/Managing Member
Avidity Partners Management (GP) LLC	7.6%	2.05M	2.05M	By: /s/ Michael Gregory	Michael Gregory/Managing Member
Avidity Capital Partners Fund (GP) LP	7.6%	2.05M	2.05M	By Avidity Capital Partners (GP) LLC, its general partner, By: /s/ Michael Gregory	Michael Gregory/Managing Member
Avidity Capital Partners (GP) LLC	7.6%	2.05M	2.05M	By: /s/ Michael Gregory	Michael Gregory/Managing Member
Avidity Master Fund LP	2.9%	782K	782K	By Avidity Capital Partners Fund (GP) LP, its general partner, By: Avidity Capital Partners (GP) LLC, its general partner, By: /s/ Michael Gregory	Michael Gregory/Managing Member
Avidity Private Master Fund I LP	4.4%	1.17M	1.17M	By Avidity Capital Partners Fund (GP) LP, its general partner, By: Avidity Capital Partners (GP) LLC, its general partner, By: /s/ Michael Gregory	Michael Gregory/Managing Member
David Witzke	0%	0	0	By: /s/ David Witzke	David Witzke
Michael Gregory	7.6%	2.05M	2.05M	By: /s/ Michael Gregory	Michael Gregory

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