Domenico Valerio - 18 Mar 2026 Form 3 Insider Report for ProQR Therapeutics N.V. (PRQR)

Reporting relationship: Director
Issuer ticker: PRQR
Reported as of: 18 Mar 2026
Net transaction value: $0
SEC form: 3
Accepted by SEC: 18 Mar 2026, 16:08:46 UTC
Source filing: View source filing
Reporting owner signature: /s/ Pieter Erik de Ridders, Attorney-in-Fact

Key filing fact

Domenico Valerio filed Form 3 for ProQR Therapeutics N.V. (PRQR) on 18 Mar 2026.

Key facts

This page summarizes Domenico Valerio's Form 3 filing for ProQR Therapeutics N.V. (PRQR).
0 reported transactions and 11 derivative rows are listed below.
Accepted by SEC: 18 Mar 2026, 16:08.

Change

No earlier filing in this sequence is available for direct comparison.
Current net transaction value: $0.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Official SEC source

Ownership activity is grounded in SEC Form 3 disclosures.

View source filing

Reporting Owners (1)

CIK 0002117550 Primary reporting owner

Valerio Domenico

Relationship: Director
Address: PROQR THERAPEUTICS N.V., ZERNIKEDREEF 9, LEIDEN, NETHERLANDS
Signature: /s/ Pieter Erik de Ridders, Attorney-in-Fact
Signature date: 18 Mar 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

PRQR holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 420,729
Date: 18 Mar 2026
Ownership: Direct

PRQR holding

Ordinary Shares

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 304,963
Date: 18 Mar 2026
Ownership: See footnote
Footnotes: F1

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 5,815
Exercise price: $4.89
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 32,164
Exercise price: $4.90
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 27,500
Exercise price: $3.30
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 14,918
Exercise price: $15.78
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 24,615
Exercise price: $9.91
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 23,239
Exercise price: $4.20
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 23,931
Exercise price: $8.01
Footnotes: F2

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 22,608
Exercise price: $3.41
Footnotes: F3

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 23,489
Exercise price: $1.98
Footnotes: F4

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 22,128
Exercise price: $2.65
Footnotes: F5

PRQR holding Derivative

Share Option (Right to Buy)

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after
Date: 18 Mar 2026
Ownership: Direct
Underlying class: Ordinary Shares
Underlying amount: 25,192
Exercise price: $2.02
Footnotes: F6

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 6 footnotes

Footnote F1

Shares held by Valerio family foundation, Stichting Administratiekantoor Endavit, for which the Reporting Person is the managing director. The Reporting Person disclaims beneficial ownership of such shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of his pecuniary interest therein, if any. This report shall not be deemed an admission that the Reporting Person is a beneficial owner of such shares for purposes of Section 16 of the Exchange Act, or for any other purpose.

Footnote F2

Fully vested.

Footnote F3

25% of the shares subject to such option vest and become exercisable on January 1, 2024, and the remaining 75% vest in 12 substantially equal quarterly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Footnote F4

25% of the shares subject to such option vest and become exercisable on January 1, 2025, and the remaining 75% vest in 12 substantially equal quarterly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Footnote F5

25% of the shares subject to such option vest and become exercisable on January 1, 2026, and the remaining 75% vest in 12 substantially equal quarterly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Footnote F6

25% of the shares subject to such option vest and become exercisable on January 1, 2027, and the remaining 75% vest in 12 substantially equal quarterly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC remarks

Exhibit 24 - Power of Attorney

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