Suma M. Krishnan - 04 Mar 2026 Form 4 Insider Report for Krystal Biotech, Inc. (KRYS)

Reporting relationship: President, R&D, Director, 10%+ Owner
Issuer ticker: KRYS
Reported as of: 04 Mar 2026
Net transaction value: -$6,580,270
SEC form: 4
Accepted by SEC: 06 Mar 2026, 18:23:09 UTC
Prior SEC filing: 03 Mar 2026
Next SEC filing: 05 Jun 2026
Source filing: View source filing
Reporting owner signature: /s/ Suma M. Krishnan

Key filing fact

Suma M. Krishnan filed Form 4 for Krystal Biotech, Inc. (KRYS) on 06 Mar 2026.

Key facts

This page summarizes Suma M. Krishnan's Form 4 filing for Krystal Biotech, Inc. (KRYS).
10 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 06 Mar 2026, 18:23.

Change

Previous filing in this sequence was filed on 03 Mar 2026.
Current net transaction value: -$6,580,270.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001298711 Primary reporting owner

Krishnan Suma

Relationship: President, R&D, Director, 10%+ Owner
Address: C/O KRYSTAL BIOTECH, INC., 2100 WHARTON STREET, SUITE 701, PITTSBURGH
Signature: /s/ Suma M. Krishnan
Signature date: 06 Mar 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

KRYS transaction

Common Stock

Sale

Transaction value: $104,729
Shares: -407
Change %: -0.03%
Price: $257.32
Shares after: 1,427,748
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F1, F2, F3

KRYS transaction

Common Stock

Sale

Transaction value: $152,280
Shares: -589
Change %: -0.04%
Price: $258.54
Shares after: 1,427,159
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F4

KRYS transaction

Common Stock

Sale

Transaction value: $173,419
Shares: -668
Change %: -0.05%
Price: $259.61
Shares after: 1,426,491
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F5

KRYS transaction

Common Stock

Sale

Transaction value: $954,762
Shares: -3,667
Change %: -0.26%
Price: $260.37
Shares after: 1,422,824
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F6

KRYS transaction

Common Stock

Sale

Transaction value: $766,198
Shares: -2,931
Change %: -0.21%
Price: $261.41
Shares after: 1,419,893
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F7

KRYS transaction

Common Stock

Sale

Transaction value: $508,430
Shares: -1,938
Change %: -0.14%
Price: $262.35
Shares after: 1,417,955
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F8

KRYS transaction

Common Stock

Sale

Transaction value: $592,535
Shares: -2,248
Change %: -0.16%
Price: $263.58
Shares after: 1,415,707
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F9

KRYS transaction

Common Stock

Sale

Transaction value: $1,284,019
Shares: -4,852
Change %: -0.34%
Price: $264.64
Shares after: 1,410,855
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F10

KRYS transaction

Common Stock

Sale

Transaction value: $1,590,979
Shares: -6,000
Change %: -0.43%
Price: $265.16
Shares after: 1,404,855
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F11

KRYS transaction

Common Stock

Sale

Transaction value: $452,918
Shares: -1,700
Change %: -0.12%
Price: $266.42
Shares after: 1,403,155
Date: 04 Mar 2026
Ownership: Direct
Footnotes: F12

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 90,000
Date: 04 Mar 2026
Ownership: By SMK Trust

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 50,000
Date: 04 Mar 2026
Ownership: By Krishnan Family Trust
Footnotes: F13

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 13 footnotes

Footnote F1

The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Krish S. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by her spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.

Footnote F2

The sales reported in this Form 4 were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025 and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan.

Footnote F3

The transaction was executed in multiple trades ranging from $256.68 to $257.67. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F4

The transaction was executed in multiple trades ranging from $257.93 to $258.92. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F5

The transaction was executed in multiple trades ranging from $258.98 to $259.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F6

The transaction was executed in multiple trades ranging from $259.98 to $260.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F7

The transaction was executed in multiple trades ranging from $261 to $261.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F8

The transaction was executed in multiple trades ranging from $262 to $262.8. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F9

The transaction was executed in multiple trades ranging from $263 to $263.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F10

The transaction was executed in multiple trades ranging from $264 to $264.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F11

The transaction was executed in multiple trades ranging from $265 to $265.73. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F12

The transaction was executed in multiple trades ranging from $266 to $266.93. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F13

Directly beneficially owned by the Krishnan Family Trust. The Reporting Person and her spouse are each joint beneficial owners of the trust with joint voting and investment control, and holdings and transactions by the Krishnan Family Trust are also reflected on the separate Form 4 filed by her spouse.