Mark E. Saad - 31 Dec 2025 Form 4 Insider Report for Axsome Therapeutics, Inc. (AXSM)

Reporting relationship: Director
Issuer ticker: AXSM
Reported as of: 31 Dec 2025
Net transaction value: -$6,001,834
SEC form: 4
Accepted by SEC: 02 Jan 2026, 19:02:02 UTC
Prior SEC filing: 05 Sep 2025
Next SEC filing: 09 Jun 2026
Source filing: View source filing
Reporting owner signature: /s/ Nick Pizzie, Attorney-in-Fact

Key filing fact

Mark E. Saad filed Form 4 for Axsome Therapeutics, Inc. (AXSM) on 02 Jan 2026.

Key facts

This page summarizes Mark E. Saad's Form 4 filing for Axsome Therapeutics, Inc. (AXSM).
6 reported transactions and 2 derivative rows are listed below.
Accepted by SEC: 02 Jan 2026, 19:02.

Change

Previous filing in this sequence was filed on 05 Sep 2025.
Current net transaction value: -$6,001,834.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001295913 Primary reporting owner

Saad Mark E

Relationship: Director
Address: C/O AXSOME THERAPEUTICS, INC., ONE WORLD TRADE CENTER, 29TH FLOOR, NEW YORK
Signature: /s/ Nick Pizzie, Attorney-in-Fact
Signature date: 02 Jan 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

AXSM transaction

Common Stock

Options Exercise

Transaction value: $49,973
Shares: +6,231
Change %: +62%
Price: $8.02
Shares after: 16,233
Date: 31 Dec 2025
Ownership: Direct
Footnotes: F1, F2

AXSM transaction

Common Stock

Sale

Transaction value: $1,029,237
Shares: -6,231
Change %: -38%
Price: $165.18
Shares after: 10,002
Date: 31 Dec 2025
Ownership: Direct
Footnotes: F2, F3, F4

AXSM transaction

Common Stock

Options Exercise

Transaction value: $155,163
Shares: +31,346
Change %: +313%
Price: $4.95
Shares after: 41,348
Date: 31 Dec 2025
Ownership: Direct
Footnotes: F1, F2

AXSM transaction

Common Stock

Sale

Transaction value: $5,177,732
Shares: -31,346
Change %: -76%
Price: $165.18
Shares after: 10,002
Date: 31 Dec 2025
Ownership: Direct
Footnotes: F2, F3, F4

AXSM holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 300
Date: 31 Dec 2025
Ownership: See explanation 5 below.
Footnotes: F5

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

AXSM transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value: $0
Shares: -6,231
Change %: -100%
Price: $0.000000
Shares after: 0
Date: 31 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 6,231
Exercise price: $8.02
Footnotes: F1, F2

AXSM transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value: $0
Shares: -31,346
Change %: -100%
Price: $0.000000
Shares after: 0
Date: 31 Dec 2025
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 31,346
Exercise price: $4.95
Footnotes: F1, F2

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 5 footnotes

Footnote F1

Represents an exercise of stock options prior to the 10-year expiration date of such options.

Footnote F2

Such transaction was pursuant to a pre-approved 10b5-1 plan.

Footnote F3

Represents the subsequent sale of the underlying shares of the aforementioned exercise of stock options.

Footnote F4

Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $165.00 and $166.09.

Footnote F5

Represents additional shares held indirectly by the Reporting Person prior to December 31, 2025 which includes shares indirectly beneficially owned by Mr. Saad as custodian for his children's UTMA accounts.