Key facts
- This page summarizes Et al Phillip Frost MD's Form 4 filing for OPKO HEALTH, INC. (OPK).
- 5 reported transactions and 0 derivative rows are listed below.
- Accepted by SEC: 21 Nov 2025, 17:07.
Et al Phillip Frost MD - 21 Nov 2025 Form 4 Insider Report for OPKO HEALTH, INC. (OPK)
- Reporting relationship
- CEO & Chairman, Director, 10%+ Owner
- Issuer ticker
- OPK
- Reported as of
- 21 Nov 2025
- Net transaction value
- +$768,807
- SEC form
- 4
- Accepted by SEC
- 21 Nov 2025, 17:07:09 UTC
- Prior SEC filing
- 20 Nov 2025
- Next SEC filing
- 25 Nov 2025
- Source filing
- View source filing
- Reporting owner signature
- Phillip Frost, M.D., Individually and as Trustee
Source evidence
Original filing metadata and source links for verification.
5 source fields
Reporting owner
1 detail
Key filing fact
Et al Phillip Frost MD filed Form 4 for OPKO HEALTH, INC. (OPK) on 21 Nov 2025.
Change
- Previous filing in this sequence was filed on 20 Nov 2025.
- Current net transaction value: +$768,807.
Research use
- This tells you what this filing adds before you inspect full transaction and derivative tables.
- You can trace every row back to the original SEC filing document.
Evidence
Filed on Form 4
View source filing
Ownership activity is grounded in SEC Form 4 disclosures.
Reporting Owners (2)
CIK 0000898860
Primary reporting owner
FROST PHILLIP MD ET AL
- Relationship
- CEO & Chairman, Director, 10%+ Owner
- Address
- OPKO HEALTH, INC., 4400 BISCAYNE BLVD., MIAMI
- Signature
- Phillip Frost, M.D., Individually and as Trustee
- Signature date
- 21 Nov 2025
CIK 0001380896
Frost Gamma Investments Trust
- Relationship
- 10%+ Owner
- Address
- OPKO HEALTH, INC., 4400 BISCAYNE BLVD., MIAMI
- Signature
- Phillip Frost, M.D., Individually and as Trustee
- Signature date
- 21 Nov 2025
Reported non-derivative transactions
Shares, units, or other non-derivative securities reported in this filing.
OPK
transaction
Common Stock
Purchase
- Transaction value
- $133,082
- Shares
- +102,371
- Change %
- +0.05%
- Price
- $1.30
- Shares after
- 216,228,819
- Date
- 21 Nov 2025
- Ownership
- See Footnote
- Footnotes
- F1
OPK
transaction
Common Stock
Purchase
- Transaction value
- $5,140
- Shares
- +3,894
- Change %
- +0%
- Price
- $1.32
- Shares after
- 216,232,713
- Date
- 21 Nov 2025
- Ownership
- See Footnote
- Footnotes
- F1
OPK
transaction
Common Stock
Purchase
- Transaction value
- $118,422
- Shares
- +89,375
- Change %
- +0.04%
- Price
- $1.32
- Shares after
- 216,322,088
- Date
- 21 Nov 2025
- Ownership
- See Footnote
- Footnotes
- F1
OPK
transaction
Common Stock
Purchase
- Transaction value
- $254,682
- Shares
- +191,490
- Change %
- +0.09%
- Price
- $1.33
- Shares after
- 216,513,578
- Date
- 21 Nov 2025
- Ownership
- See Footnote
- Footnotes
- F1
OPK
transaction
Common Stock
Purchase
- Transaction value
- $257,481
- Shares
- +192,870
- Change %
- +0.09%
- Price
- $1.34
- Shares after
- 216,706,448
- Date
- 21 Nov 2025
- Ownership
- See Footnote
- Footnotes
- F1
OPK
holding
Common Stock
No transaction description listed
- Transaction value
- Shares
- Change %
- Price
- Shares after
- 3,568,951
- Date
- 21 Nov 2025
- Ownership
- Direct
OPK
holding
Common Stock
No transaction description listed
- Transaction value
- Shares
- Change %
- Price
- Shares after
- 30,127,177
- Date
- 21 Nov 2025
- Ownership
- See Footnote
- Footnotes
- F2
* marks a reported price that did not pass the local price check.
Additional SEC filing notes
Filing notes and footnotes
Explanation of responses 2 footnotes
Footnote F1
The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
Footnote F2
These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.