SR ONE CAPITAL MANAGEMENT, LLC - 09 Oct 2025 Form 4 Insider Report for Zenas BioPharma, Inc. (ZBIO)

Reporting relationship: 10%+ Owner
Issuer ticker: ZBIO
Reported as of: 09 Oct 2025
Net transaction value: +$2,399,985
SEC form: 4
Accepted by SEC: 14 Oct 2025, 17:14:56 UTC
Prior SEC filing: 16 Sep 2024
Next SEC filing: 29 Apr 2026
Source filing: View source filing
Reporting owner signature: /s/ Sasha Keough, attorney-in-fact for SR One Capital Management, LLC

Key filing fact

SR ONE CAPITAL MANAGEMENT, LLC filed Form 4 for Zenas BioPharma, Inc. (ZBIO) on 14 Oct 2025.

Key facts

This page summarizes SR ONE CAPITAL MANAGEMENT, LLC's Form 4 filing for Zenas BioPharma, Inc. (ZBIO).
2 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 14 Oct 2025, 17:14.

Change

Previous filing in this sequence was filed on 16 Sep 2024.
Current net transaction value: +$2,399,985.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (2)

CIK 0001853723 Primary reporting owner

SR ONE CAPITAL MANAGEMENT, LLC

Relationship: 10%+ Owner
Address: 985 OLD EAGLE SCHOOL ROAD, SUITE 511, WAYNE
Signature: /s/ Sasha Keough, attorney-in-fact for SR One Capital Management, LLC
Signature date: 14 Oct 2025

CIK 0001595117

George Simeon

Relationship: 10%+ Owner
Address: 985 OLD EAGLE SCHOOL ROAD, SUITE 511, WAYNE
Signature: /s/ Sasha Keough, attorney-in-fact for Simeon George
Signature date: 14 Oct 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

ZBIO transaction

Common Stock

Purchase

Transaction value: $1,200,002
Shares: +63,158
Change %: +5.7%
Price: $19.00
Shares after: 1,173,395
Date: 09 Oct 2025
Ownership: See Note 2
Footnotes: F1, F2

ZBIO transaction

Common Stock

Purchase

Transaction value: $1,199,983
Shares: +63,157
Change %: +3.4%
Price: $19.00
Shares after: 1,917,895
Date: 09 Oct 2025
Ownership: See Note 3
Footnotes: F1, F3

ZBIO holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 1,946,564
Date: 09 Oct 2025
Ownership: See Note 4
Footnotes: F4

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Section 16 status

SR ONE CAPITAL MANAGEMENT, LLC is no longer subject to Section 16 filing requirements. Form 4 or Form 5 obligations may still apply in specific circumstances.

Explanation of responses 4 footnotes

Footnote F1

Acquired from the Issuer on October 9, 2025 pursuant to a Securities Purchase Agreement dated October 7, 2025.

Footnote F2

The reported securities are held directly by SR One Capital Opportunities Fund I, LP. SR One Capital Opportunities Partners I, LP is the general partner of SR One Capital Opportunities Fund I, LP, and SR One Capital Management, LLC is the general partner of SR One Capital Opportunities Partners I, LP. Simeon George, M.D. is the managing member of SR One Capital Management, LLC. Each of SR One Capital Opportunities Partners I, LP, SR One Capital Management, LLC and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.

Footnote F3

The reported securities are held directly by AMZL, LP. SR One Capital SMA Partners, LP is the general partner of AMZL, LP, and SR One Capital Management, LLC is the general partner of SR One Capital SMA Partners, LP. Simeon George, M.D. is the managing member of SR One Capital Management, LLC. Each of SR One Capital SMA Partners, LP, SR One Capital Management, LLC and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.

Footnote F4

The reported securities are held directly by SR One Capital Fund II Aggregator, LP. SR One Capital Partners II, LP is the general partner of SR One Capital Fund II Aggregator, LP, and SR One Capital Management, LLC is the general partner of SR One Capital Partners II, LP. Simeon George, M.D. is the managing member of SR One Capital Management, LLC. Each of SR One Capital Partners II, LP, SR One Capital Management, LLC and Dr. George may be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.