EcoR1 Capital, LLC - 26 Jun 2025 Form 4 Insider Report for Zymeworks Inc. (ZYME)

Reporting relationship: Director, 10%+ Owner
Issuer ticker: ZYME
Reported as of: 26 Jun 2025
Net transaction value: -$12.46
SEC form: 4
Accepted by SEC: 27 Jun 2025, 17:50:21 UTC
Prior SEC filing: 19 May 2025
Next SEC filing: 30 Jul 2025
Source filing: View source filing
Reporting owner signature: /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC

Key filing fact

EcoR1 Capital, LLC filed Form 4 for Zymeworks Inc. (ZYME) on 27 Jun 2025.

Key facts

This page summarizes EcoR1 Capital, LLC's Form 4 filing for Zymeworks Inc. (ZYME).
3 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 27 Jun 2025, 17:50.

Change

Previous filing in this sequence was filed on 19 May 2025.
Current net transaction value: -$12.46.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (2)

CIK 0001587114 Primary reporting owner

EcoR1 Capital, LLC

Relationship: Director, 10%+ Owner
Address: 357 TEHAMA STREET #3, SAN FRANCISCO
Signature: /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC
Signature date: 27 Jun 2025

CIK 0001454385

NODELMAN OLEG

Relationship: Director, 10%+ Owner
Address: 357 TEHAMA STREET #3, SAN FRANCISCO
Signature: /s/ Oleg Nodelman, Individually and as Manager of EcoR1 Capital, LLC
Signature date: 27 Jun 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

ZYME transaction

Common Stock

Exercise of in-the-money or at-the-money derivative security

Transaction value: $509
Shares: +5,086,480
Change %: +28%
Price: $0.000100
Shares after: 22,970,388
Date: 26 Jun 2025
Ownership: See Note
Footnotes: F1, F2, F3

ZYME transaction

Common Stock

Tax liability

Transaction value: $521
Shares: -41
Change %: -0%
Price: $12.71
Shares after: 22,970,388
Date: 26 Jun 2025
Ownership: See Note
Footnotes: F1, F3, F4

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

ZYME transaction Derivative

Pre-Funded Warrants (right to acquire)

Exercise of in-the-money or at-the-money derivative security

Transaction value: $0
Shares: -5,086,521
Change %: -100%
Price: $0.000000
Shares after: 0
Date: 26 Jun 2025
Ownership: See note
Underlying class: Common Stock
Underlying amount: 5,086,521
Exercise price: $0.000100
Footnotes: F1, F5, F6

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 6 footnotes

Footnote F1

The reporting persons are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself and Qualified Fund. The filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to indirectly beneficially own them as the investment adviser to the Funds. Mr. Nodelman may be deemed to indirectly beneficially own them as the control person of EcoR1. The filers disclaim beneficial ownership of the securities except to the extent of their respective pecuniary interests therein.

Footnote F2

Qualified Fund acquired 4,818,424 shares of Common Stock in connection with the exercise of the pre-funded warrants.

Footnote F3

After the transactions reported herein, Qualified Fund held 21,582,563 shares of the Issuer's Common Stock.

Footnote F4

On June 26, 2025,the reporting persons exercised pre-funded warrants to purchase 5,086,521 shares of the Issuer's Common Stock for $0.0001 per share. The reporting persons paid the exercise price on a cashless basis, resulting in the Issuer withholding 41 of the warrant shares (including 38 warrant shares issuable to Qualified Fund) to pay the exercise price and issuing to the reporting persons the remaining 5,086,480 shares.

Footnote F5

Qualified Fund exercised 4,818,462 of the pre-funded warrants reported in this transaction.

Footnote F6

The pre-funded warrants did not have an expiration date.

SEC remarks

Mr. Nodelman is a director of the Issuer. Scott Platshon, an employee of EcoR1, also serves as a director of the Issuer and was nominated for the board by EcoR1 and the Funds.