RA CAPITAL MANAGEMENT, L.P. - 12 Jun 2025 Form 4 Insider Report for Tyra Biosciences, Inc. (TYRA)

Reporting relationship: Director, 10%+ Owner
Issuer ticker: TYRA
Reported as of: 12 Jun 2025
Net transaction value: +$1,664,700
SEC form: 4
Accepted by SEC: 16 Jun 2025, 20:06:50 UTC
Prior SEC filing: 11 Jun 2025
Next SEC filing: 17 Jun 2025
Source filing: View source filing
Reporting owner signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.

Key filing fact

RA CAPITAL MANAGEMENT, L.P. filed Form 4 for Tyra Biosciences, Inc. (TYRA) on 16 Jun 2025.

Key facts

This page summarizes RA CAPITAL MANAGEMENT, L.P.'s Form 4 filing for Tyra Biosciences, Inc. (TYRA).
3 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 16 Jun 2025, 20:06.

Change

Previous filing in this sequence was filed on 11 Jun 2025.
Current net transaction value: +$1,664,700.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (5)

CIK 0001346824 Primary reporting owner

RA CAPITAL MANAGEMENT, L.P.

Relationship: Director, 10%+ Owner
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.
Signature date: 16 Jun 2025

CIK 0001315082

RA Capital Healthcare Fund LP

Relationship: Director, 10%+ Owner
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC the General Partner of RA Capital Healthcare Fund, L.P.
Signature date: 16 Jun 2025

CIK 0001780117

RA Capital Nexus Fund, L.P.

Relationship: Director
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund GP, LLC the General Partner of RA Capital Nexus Fund, L.P.
Signature date: 16 Jun 2025

CIK 0001384859

Kolchinsky Peter

Relationship: Director, 10%+ Owner
Address: C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, individually
Signature date: 16 Jun 2025

CIK 0001619841

Shah Rajeev M.

Relationship: Director, 10%+ Owner
Address: C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Rajeev Shah, individually
Signature date: 16 Jun 2025

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

TYRA transaction

Common Stock

Purchase

Transaction value: $319,331
Shares: +31,307
Change %: +0.31%
Price: $10.20
Shares after: 10,127,311
Date: 12 Jun 2025
Ownership: See footnotes
Footnotes: F1, F2, F3

TYRA transaction

Common Stock

Purchase

Transaction value: $1,225,703
Shares: +120,167
Change %: +1.2%
Price: $10.20
Shares after: 10,247,478
Date: 13 Jun 2025
Ownership: See footnotes
Footnotes: F2, F3, F4

TYRA transaction

Common Stock

Purchase

Transaction value: $119,666
Shares: +11,813
Change %: +0.12%
Price: $10.13
Shares after: 10,259,291
Date: 16 Jun 2025
Ownership: See footnotes
Footnotes: F2, F3, F5

TYRA holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 1,496,613
Date: 12 Jun 2025
Ownership: See footnotes
Footnotes: F3, F6

TYRA holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 442,721
Date: 12 Jun 2025
Ownership: See footnotes
Footnotes: F3, F7

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 7 footnotes

Footnote F1

The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.17 to $10.20 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

Footnote F2

These securities are held directly by the RA Capital Healthcare Fund, L.P. (the "Fund").

Footnote F3

RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

Footnote F4

The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.09 to $10.20 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

Footnote F5

The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $10.12 to $10.20 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

Footnote F6

These securities are held directly by the Nexus Fund.

Footnote F7

These securities are held directly by the Account.

SEC remarks

Jake Simson, a Partner of the Adviser, serves on the Issuer's board of directors.