Heidy King-Jones - 01 Oct 2026 Form 4 Insider Report for Spyre Therapeutics, Inc. (SYRE)

Reporting relationship: Chief Legal Officer and Corporate Secretary
Issuer ticker: SYRE
Reported as of: 01 Oct 2026
Net transaction value: -$2,633,902
SEC form: 4
Accepted by SEC: 02 Oct 2026, 21:30:15 UTC
Prior SEC filing: 03 Sep 2026
Source filing: View source filing
Reporting owner signature: /s/ Heidy King-Jones

Filing notes and source

Key filing fact

Heidy King-Jones filed Form 4 for Spyre Therapeutics, Inc. (SYRE) on 02 Oct 2026.

Key facts

This page summarizes Heidy King-Jones's Form 4 filing for Spyre Therapeutics, Inc. (SYRE).
7 reported transactions and 1 derivative row are listed below.
Accepted by SEC: 02 Oct 2026, 21:30.

Change

Previous filing in this sequence was filed on 03 Sep 2026.
Current net transaction value: -$2,633,902.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001794898 Primary reporting owner

King-Jones Heidy

Relationship: Chief Legal Officer and Corporate Secretary
Address: 221 CRESCENT STREET, BUILDING 23,, SUITE 105, WALTHAM
Signature: /s/ Heidy King-Jones
Signature date: 02 Oct 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

SYRE transaction

Common Stock

Options Exercise

Transaction value
Shares: +28,933
Change %: +1017%
Price: $14.50^*
Shares after: 31,778
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1

SYRE transaction

Common Stock

Sale

Transaction value: $35,696
Shares: -400
Change %: -1.3%
Price: $89.24
Shares after: 31,378
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F2

SYRE transaction

Common Stock

Sale

Transaction value: $1,500,262
Shares: -16,605
Change %: -53%
Price: $90.35
Shares after: 14,773
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F3

SYRE transaction

Common Stock

Sale

Transaction value: $660,278
Shares: -7,228
Change %: -49%
Price: $91.35
Shares after: 7,545
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F4

SYRE transaction

Common Stock

Sale

Transaction value: $194,670
Shares: -2,100
Change %: -28%
Price: $92.70
Shares after: 5,445
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F5

SYRE transaction

Common Stock

Sale

Transaction value: $242,996
Shares: -2,600
Change %: -48%
Price: $93.46
Shares after: 2,845
Date: 01 Oct 2026
Ownership: Direct
Footnotes: F1, F6

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

SYRE transaction Derivative

Stock Option (Right to Buy)

Options Exercise

Transaction value
Shares: -28,933
Change %: -5.7%
Price: $0.000000^*
Shares after: 482,478
Date: 01 Oct 2026
Ownership: Direct
Underlying class: Common Stock
Underlying amount: 28,933
Exercise price: $14.50
Footnotes: F1, F7

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 7 footnotes

Footnote F1

This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on April 16, 2026.

Footnote F2

The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $88.63 to $89.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

Footnote F3

The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $89.96 to $90.95, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

Footnote F4

The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $91.10 to $92.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

Footnote F5

The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $92.12 to $93.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

Footnote F6

The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $93.17 to $93.75, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

Footnote F7

This option represents the right to purchase 539,810 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.

SEC remarks

Chief Legal Officer and Corporate Secretary