RA CAPITAL MANAGEMENT, L.P. - 15 Sep 2026 Form 4 Insider Report for Tyra Biosciences, Inc. (TYRA)

Reporting relationship: Director, 10%+ Owner
Issuer ticker: TYRA
Reported as of: 15 Sep 2026
Net transaction value: +$199,990,915
SEC form: 4
Accepted by SEC: 17 Sep 2026, 16:31:47 UTC
Prior SEC filing: 14 Sep 2026
Next SEC filing: 21 Sep 2026
Source filing: View source filing
Reporting owner signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.

Key filing fact

RA CAPITAL MANAGEMENT, L.P. filed Form 4 for Tyra Biosciences, Inc. (TYRA) on 17 Sep 2026.

Key facts

This page summarizes RA CAPITAL MANAGEMENT, L.P.'s Form 4 filing for Tyra Biosciences, Inc. (TYRA).
1 reported transaction and 5 derivative rows are listed below.
Accepted by SEC: 17 Sep 2026, 16:31.

Change

Previous filing in this sequence was filed on 14 Sep 2026.
Current net transaction value: +$199,990,915.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (5)

CIK 0001346824 Primary reporting owner

RA CAPITAL MANAGEMENT, L.P.

Relationship: Director, 10%+ Owner
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.
Signature date: 17 Sep 2026

CIK 0001315082

RA Capital Healthcare Fund LP

Relationship: Director, 10%+ Owner
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC the General Partner of RA Capital Healthcare Fund, L.P.
Signature date: 17 Sep 2026

CIK 0001780117

RA Capital Nexus Fund, L.P.

Relationship: Director
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund GP, LLC the General Partner of RA Capital Nexus Fund, L.P.
Signature date: 17 Sep 2026

CIK 0001384859

Kolchinsky Peter

Relationship: Director, 10%+ Owner
Address: C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, individually
Signature date: 17 Sep 2026

CIK 0001619841

Shah Rajeev M.

Relationship: Director, 10%+ Owner
Address: C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Rajeev Shah, individually
Signature date: 17 Sep 2026

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

TYRA transaction Derivative

Pre-Funded Warrants (Right to Buy)

Purchase

Transaction value: $199,990,915
Shares: +9,078,529
Change %: +358%
Price: $22.03
Shares after: 11,616,986
Date: 15 Sep 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 9,078,529
Exercise price: $0.001000
Footnotes: F1, F2, F3

TYRA transaction Derivative

Pre-Funded Warrants (Right to Buy)

Purchase

Transaction value: $199,990,915
Shares: +9,078,529
Change %: +358%
Price: $22.03
Shares after: 11,616,986
Date: 15 Sep 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 9,078,529
Exercise price: $0.001000
Footnotes: F1, F2, F3

TYRA transaction Derivative

Pre-Funded Warrants (Right to Buy)

Purchase

Transaction value: $199,990,915
Shares: +9,078,529
Change %: +358%
Price: $22.03
Shares after: 11,616,986
Date: 15 Sep 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 9,078,529
Exercise price: $0.001000
Footnotes: F1, F2, F3

TYRA transaction Derivative

Pre-Funded Warrants (Right to Buy)

Purchase

Transaction value: $199,990,915
Shares: +9,078,529
Change %: +358%
Price: $22.03
Shares after: 11,616,986
Date: 15 Sep 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 9,078,529
Exercise price: $0.001000
Footnotes: F1, F2, F3

TYRA transaction Derivative

Pre-Funded Warrants (Right to Buy)

Purchase

Transaction value: $199,990,915
Shares: +9,078,529
Change %: +358%
Price: $22.03
Shares after: 11,616,986
Date: 15 Sep 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 9,078,529
Exercise price: $0.001000
Footnotes: F1, F2, F3

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 3 footnotes

Footnote F1

The Pre-Funded Warrants have no expiration date and are exercisable immediately. Notwithstanding the foregoing, the Reporting Persons shall not be entitled to exercise the Pre-Funded Warrants to the extent that it would cause the aggregate number of shares of Common Stock beneficially owned by the Reporting Persons, their affiliates and any persons who are members of a Section 13(d) group with the Reporting Persons or their affiliates to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.

Footnote F2

RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

Footnote F3

Held directly by the Fund.

SEC remarks

Jake Simson, a Partner of the Adviser, serves on the Issuer's board of directors.