Krish S. Krishnan - 04 Sep 2026 Form 4 Insider Report for Krystal Biotech, Inc. (KRYS)

Reporting relationship: President and CEO, Director, 10%+ Owner
Issuer ticker: KRYS
Reported as of: 04 Sep 2026
Net transaction value: -$8,983,084
SEC form: 4
Accepted by SEC: 04 Sep 2026, 19:14:09 UTC
Prior SEC filing: 05 Jun 2026
Source filing: View source filing
Reporting owner signature: /s/ Krish S. Krishnan

Key filing fact

Krish S. Krishnan filed Form 4 for Krystal Biotech, Inc. (KRYS) on 04 Sep 2026.

Key facts

This page summarizes Krish S. Krishnan's Form 4 filing for Krystal Biotech, Inc. (KRYS).
13 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 04 Sep 2026, 19:14.

Change

Previous filing in this sequence was filed on 05 Jun 2026.
Current net transaction value: -$8,983,084.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001298709 Primary reporting owner

Krishnan Krish S

Relationship: President and CEO, Director, 10%+ Owner
Address: C/O KRYSTAL BIOTECH, INC., 2100 WHARTON STREET, SUITE 701, PITTSBURGH
Signature: /s/ Krish S. Krishnan
Signature date: 04 Sep 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

KRYS transaction

Common Stock

Sale

Transaction value: $184,361
Shares: -520
Change %: -0.04%
Price: $354.54
Shares after: 1,372,023
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F1, F2, F3

KRYS transaction

Common Stock

Sale

Transaction value: $721,455
Shares: -2,029
Change %: -0.15%
Price: $355.57
Shares after: 1,369,994
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F4

KRYS transaction

Common Stock

Sale

Transaction value: $1,174,948
Shares: -3,297
Change %: -0.24%
Price: $356.37
Shares after: 1,366,697
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F5

KRYS transaction

Common Stock

Sale

Transaction value: $1,423,501
Shares: -3,981
Change %: -0.29%
Price: $357.57
Shares after: 1,362,716
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F6

KRYS transaction

Common Stock

Sale

Transaction value: $1,126,508
Shares: -3,143
Change %: -0.23%
Price: $358.42
Shares after: 1,359,573
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F7

KRYS transaction

Common Stock

Sale

Transaction value: $1,206,459
Shares: -3,357
Change %: -0.25%
Price: $359.39
Shares after: 1,356,216
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F8

KRYS transaction

Common Stock

Sale

Transaction value: $816,809
Shares: -2,266
Change %: -0.17%
Price: $360.46
Shares after: 1,353,950
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F9

KRYS transaction

Common Stock

Sale

Transaction value: $438,993
Shares: -1,214
Change %: -0.09%
Price: $361.61
Shares after: 1,352,736
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F10

KRYS transaction

Common Stock

Sale

Transaction value: $728,927
Shares: -2,010
Change %: -0.15%
Price: $362.65
Shares after: 1,350,726
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F11

KRYS transaction

Common Stock

Sale

Transaction value: $208,195
Shares: -573
Change %: -0.04%
Price: $363.34
Shares after: 1,350,153
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F12

KRYS transaction

Common Stock

Sale

Transaction value: $494,963
Shares: -1,358
Change %: -0.1%
Price: $364.48
Shares after: 1,348,795
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F13

KRYS transaction

Common Stock

Sale

Transaction value: $309,508
Shares: -847
Change %: -0.06%
Price: $365.42
Shares after: 1,347,948
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F14

KRYS transaction

Common Stock

Sale

Transaction value: $148,455
Shares: -405
Change %: -0.03%
Price: $366.56
Shares after: 1,347,543
Date: 04 Sep 2026
Ownership: Direct
Footnotes: F15

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 90,000
Date: 04 Sep 2026
Ownership: By SMK Trust FBO KSK
Footnotes: F16

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 77,710
Date: 04 Sep 2026
Ownership: By Krish Srinivas Krishnan Trust
Footnotes: F17

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 50,000
Date: 04 Sep 2026
Ownership: By Krishnan Family Trust
Footnotes: F18

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 18 footnotes

Footnote F1

The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

Footnote F2

The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

Footnote F3

The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F4

The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F5

The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F6

The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F7

The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F8

The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F9

The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F10

The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F11

The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F12

The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F13

The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F14

The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F15

The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F16

Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.

Footnote F17

Held by the Krish Srinivas Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.

Footnote F18

Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.