Krish S. Krishnan - 04 Jun 2026 Form 4 Insider Report for Krystal Biotech, Inc. (KRYS)

Reporting relationship: President and CEO, Director, 10%+ Owner
Issuer ticker: KRYS
Reported as of: 04 Jun 2026
Net transaction value: -$7,702,984
SEC form: 4
Accepted by SEC: 05 Jun 2026, 18:38:36 UTC
Prior SEC filing: 06 Mar 2026
Source filing: View source filing
Reporting owner signature: /s/ Krish S. Krishnan

Key filing fact

Krish S. Krishnan filed Form 4 for Krystal Biotech, Inc. (KRYS) on 05 Jun 2026.

Key facts

This page summarizes Krish S. Krishnan's Form 4 filing for Krystal Biotech, Inc. (KRYS).
11 reported transactions and 0 derivative rows are listed below.
Accepted by SEC: 05 Jun 2026, 18:38.

Change

Previous filing in this sequence was filed on 06 Mar 2026.
Current net transaction value: -$7,702,984.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (1)

CIK 0001298709 Primary reporting owner

Krishnan Krish S

Relationship: President and CEO, Director, 10%+ Owner
Address: C/O KRYSTAL BIOTECH, INC., 2100 WHARTON STREET, SUITE 701, PITTSBURGH
Signature: /s/ Krish S. Krishnan
Signature date: 05 Jun 2026

Reported non-derivative transactions

Shares, units, or other non-derivative securities reported in this filing.

KRYS transaction

Common Stock

Sale

Transaction value: $96,240
Shares: -320
Change %: -0.02%
Price: $300.75
Shares after: 1,474,933
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F1, F2

KRYS transaction

Common Stock

Sale

Transaction value: $193,431
Shares: -640
Change %: -0.04%
Price: $302.24
Shares after: 1,474,293
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F3

KRYS transaction

Common Stock

Sale

Transaction value: $53,358
Shares: -176
Change %: -0.01%
Price: $303.17
Shares after: 1,474,117
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F4

KRYS transaction

Common Stock

Sale

Transaction value: $165,817
Shares: -544
Change %: -0.04%
Price: $304.81
Shares after: 1,473,573
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F5

KRYS transaction

Common Stock

Sale

Transaction value: $180,429
Shares: -589
Change %: -0.04%
Price: $306.33
Shares after: 1,472,984
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F6

KRYS transaction

Common Stock

Sale

Transaction value: $3,526,293
Shares: -11,461
Change %: -0.78%
Price: $307.68
Shares after: 1,461,523
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F7

KRYS transaction

Common Stock

Sale

Transaction value: $1,489,899
Shares: -4,830
Change %: -0.33%
Price: $308.47
Shares after: 1,456,693
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F8

KRYS transaction

Common Stock

Sale

Transaction value: $861,620
Shares: -2,784
Change %: -0.19%
Price: $309.49
Shares after: 1,453,909
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F9

KRYS transaction

Common Stock

Sale

Transaction value: $823,258
Shares: -2,652
Change %: -0.18%
Price: $310.43
Shares after: 1,451,257
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F10

KRYS transaction

Common Stock

Sale

Transaction value: $300,149
Shares: -964
Change %: -0.07%
Price: $311.36
Shares after: 1,450,293
Date: 04 Jun 2026
Ownership: Direct
Footnotes: F11

KRYS transaction

Common Stock

Sale

Transaction value: $12,489
Shares: -40
Change %: -0%
Price: $312.23
Shares after: 1,450,253
Date: 04 Jun 2026
Ownership: Direct

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 90,000
Date: 04 Jun 2026
Ownership: By SMK Trust FBO KSK
Footnotes: F12

KRYS holding

Common Stock

No transaction description listed

Transaction value
Shares
Change %
Price
Shares after: 50,000
Date: 04 Jun 2026
Ownership: By Krishnan Family Trust
Footnotes: F13

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Rule 10b5-1 trading plan

These transactions were reported as open-market trades under a Rule 10b5-1 plan. The plan lets an insider set trading instructions in advance, which can reduce the risk of trading while in possession of material nonpublic information.

Original filing language: transaction made pursuant to a contract, instruction, or written plan intended to satisfy Rule 10b5-1(c).

Explanation of responses 13 footnotes

Footnote F1

The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

Footnote F2

The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan started on December 4, 2025, and will terminate on December 4, 2026, or earlier in accordance with the terms of the Rule 10b5-1 trading plan, including upon completion of the sale of all of the shares of the Company's common stock subject to the Rule 10b5-1 trading plan.

Footnote F3

The transaction was executed in multiple trades ranging from $302.05 to $303.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F4

The transaction was executed in multiple trades ranging from $303.05 to $303.82. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F5

The transaction was executed in multiple trades ranging from $304.07 to $304.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F6

The transaction was executed in multiple trades ranging from $306.00 to $306.99. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F7

The transaction was executed in multiple trades ranging from $307.03 to $308.02. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F8

The transaction was executed in multiple trades ranging from $308.03 to $309.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F9

The transaction was executed in multiple trades ranging from $309.04 to $310.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F10

The transaction was executed in multiple trades ranging from $310.06 to $311.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F11

The transaction was executed in multiple trades ranging from $311.07 to $311.77. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

Footnote F12

Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.

Footnote F13

Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.