RA CAPITAL MANAGEMENT, L.P. - 28 May 2026 Form 4 Insider Report for Tyra Biosciences, Inc. (TYRA)

Reporting relationship: Director, 10%+ Owner
Issuer ticker: TYRA
Reported as of: 28 May 2026
Net transaction value: $0
SEC form: 4
Accepted by SEC: 01 Jun 2026, 17:45:19 UTC
Prior SEC filing: 21 May 2026
Next SEC filing: 05 Jun 2026
Source filing: View source filing
Reporting owner signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.

Key filing fact

RA CAPITAL MANAGEMENT, L.P. filed Form 4 for Tyra Biosciences, Inc. (TYRA) on 01 Jun 2026.

Key facts

This page summarizes RA CAPITAL MANAGEMENT, L.P.'s Form 4 filing for Tyra Biosciences, Inc. (TYRA).
1 reported transaction and 5 derivative rows are listed below.
Accepted by SEC: 01 Jun 2026, 17:45.

Change

Previous filing in this sequence was filed on 21 May 2026.
Current net transaction value: $0.

Research use

This tells you what this filing adds before you inspect full transaction and derivative tables.
You can trace every row back to the original SEC filing document.

Evidence

Filed on Form 4

Ownership activity is grounded in SEC Form 4 disclosures.

View source filing

Reporting Owners (5)

CIK 0001346824 Primary reporting owner

RA CAPITAL MANAGEMENT, L.P.

Relationship: Director, 10%+ Owner
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P.
Signature date: 01 Jun 2026

CIK 0001315082

RA Capital Healthcare Fund LP

Relationship: Director, 10%+ Owner
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P.
Signature date: 01 Jun 2026

CIK 0001780117

RA Capital Nexus Fund, L.P.

Relationship: Director
Address: 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund GP, LLC, the General Partner of RA Capital Nexus Fund, L.P.
Signature date: 01 Jun 2026

CIK 0001384859

Kolchinsky Peter

Relationship: Director, 10%+ Owner
Address: C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Peter Kolchinsky, individually
Signature date: 01 Jun 2026

CIK 0001619841

Shah Rajeev M.

Relationship: Director, 10%+ Owner
Address: C/O RA CAPITAL MANAGEMENT, L.P., 200 BERKELEY STREET, 18TH FLOOR, BOSTON
Signature: /s/ Rajeev Shah, individually
Signature date: 01 Jun 2026

Reported derivative securities

Options, warrants, convertible securities, or similar derivative positions disclosed in the filing.

TYRA transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +13,160
Change %
Price: $0.000000^*
Shares after: 13,160
Date: 28 May 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 13,160
Exercise price: $32.68
Footnotes: F1, F2, F3

TYRA transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +13,160
Change %
Price: $0.000000^*
Shares after: 13,160
Date: 28 May 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 13,160
Exercise price: $32.68
Footnotes: F1, F2, F3

TYRA transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +13,160
Change %
Price: $0.000000^*
Shares after: 13,160
Date: 28 May 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 13,160
Exercise price: $32.68
Footnotes: F1, F2, F3

TYRA transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +13,160
Change %
Price: $0.000000^*
Shares after: 13,160
Date: 28 May 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 13,160
Exercise price: $32.68
Footnotes: F1, F2, F3

TYRA transaction Derivative

Stock Option (Right to Buy)

Award

Transaction value
Shares: +13,160
Change %
Price: $0.000000^*
Shares after: 13,160
Date: 28 May 2026
Ownership: See footnotes
Underlying class: Common Stock
Underlying amount: 13,160
Exercise price: $32.68
Footnotes: F1, F2, F3

^* marks a reported price that did not pass the local price check.

Additional SEC filing notes

Filing notes and footnotes

Explanation of responses 3 footnotes

Footnote F1

The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 28, 2026, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to Jake Simson's continuous service to the Issuer through each vesting date.

Footnote F2

RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

Footnote F3

Under Mr. Simson's arrangement with the Adviser, Mr. Simson holds the option for the benefit of the Fund, the Nexus Fund, and the Account. Mr. Simson is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock.

SEC remarks

Dr. Jake Simson, a Partner of the Adviser, serves on the Issuer's board of directors.