Kevin McCulloch - 11 Sep 2025 Form 4 Insider Report for Xeris Biopharma Holdings, Inc. (XERS)

Role: President and Chief Operating Officer
Signature: /s/ Beth Hecht, Attorney-in-Fact
Issuer symbol: XERS
Transactions as of: 11 Sep 2025
Net transactions value: $0
Form type: 4
Filing time: 15 Sep 2025, 17:33:15 UTC
Previous filing: 04 Aug 2025
Next filing: 03 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
McCulloch Kevin	President and Chief Operating Officer	C/O XERIS BIOPHARMA HOLDINGS, INC., 1375 WEST FULTON STREET, SUITE 1300, CHICAGO	/s/ Beth Hecht, Attorney-in-Fact	15 Sep 2025	0002031695

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	XERS	Common Stock	Other	$0	-2,000	-100%	$0.000000	0	11 Sep 2025	By Charles R. McCulloch Trust dated 1990	F1
holding	XERS	Common Stock						1,701,159	11 Sep 2025	Direct
holding	XERS	Common Stock						25,000	11 Sep 2025	By Spouse	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The reporting person is trustee of the Charles R. McCulloch Trust, of which he is a beneficiary. On September 11, 2025, the reporting person caused the trust to distribute 2,000 shares of the Issuer's common stock to a beneficiary of the trust. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. No sale of shares occurred in the transfer.
F2	The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

Content

The reporting person is trustee of the Charles R. McCulloch Trust, of which he is a beneficiary. On September 11, 2025, the reporting person caused the trust to distribute 2,000 shares of the Issuer's common stock to a beneficiary of the trust. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. No sale of shares occurred in the transfer.

The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

Remarks:

President and Chief Operating Officer