Manher Joshi - 10 Nov 2025 Form 4 Insider Report for SOLENO THERAPEUTICS INC (SLNO)

Role: Chief Development Officer
Signature: /s/ Anish Bhatnagar, Attorney-in-Fact
Issuer symbol: SLNO
Transactions as of: 10 Nov 2025
Net transactions value: $0
Form type: 4
Filing time: 12 Nov 2025, 17:21:09 UTC
Previous filing: 20 Nov 2023
Next filing: 23 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Joshi Manher	Chief Development Officer	100 MARINE PARKWAY, SUITE 400, REDWOOD CITY	/s/ Anish Bhatnagar, Attorney-in-Fact	12 Nov 2025	0001978048

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	SLNO	Common Stock	Award	$0	+16,071		$0.000000	16,071	10 Nov 2025	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SLNO	Employee stock option (right to buy)	Options Exercise	$0	+72,321		$0.000000	72,321	10 Nov 2025	Common Stock	72,321	$46.31	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	These securities are restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. One-half of the RSUs shall vest on November 10, 2026 and one third of the remaining RSUs shall vest each one-year anniversary thereafter, subject to the Reporting Person continuing to be a Service Provider (as defined in the Issuer's 2014 Equity Incentive Plan) through each such date.
F2	One-fourth of the shares subject to the option shall vest on November 10, 2026 and one forty-eighth of the shares subject to the option shall vest each month thereafter on the same day of the month, subject to the Reporting Person continuing to be a Service Provider (as defined in the Issuer's 2014 Equity Incentive Plan) through each such date.

Content

These securities are restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. One-half of the RSUs shall vest on November 10, 2026 and one third of the remaining RSUs shall vest each one-year anniversary thereafter, subject to the Reporting Person continuing to be a Service Provider (as defined in the Issuer's 2014 Equity Incentive Plan) through each such date.

One-fourth of the shares subject to the option shall vest on November 10, 2026 and one forty-eighth of the shares subject to the option shall vest each month thereafter on the same day of the month, subject to the Reporting Person continuing to be a Service Provider (as defined in the Issuer's 2014 Equity Incentive Plan) through each such date.