Brian Taylor Slingsby - 20 Nov 2025 Form 4 Insider Report for Mineralys Therapeutics, Inc. (MLYS)

Role: Director, 10%+ Owner
Signature: /s/ Brian Taylor Slingsby
Issuer symbol: MLYS
Transactions as of: 20 Nov 2025
Net transactions value: -$43,350,000
Form type: 4
Filing time: 21 Nov 2025, 18:07:59 UTC
Previous filing: 25 Apr 2025
Next filing: 20 Feb 2026
SEC: View on sec.gov

Reporting Owners (2)

Name	Relationship	Address	Signature	Signature date	CIK
Slingsby Brian Taylor	Director, 10%+ Owner	1700 WESTLAKE AVE. N, SUITE 200, THINKSPACE, SEATTLE	/s/ Brian Taylor Slingsby	21 Nov 2025	0001963901
Catalys Pacific Fund, LP	10%+ Owner	3RD FLOOR WHITEHALL HOUSE, 238 NORTH CHURCH STREET, GEORGE TOWN, GRAND CAYMAN, CAYMAN ISLANDS	Catalys Pacific Fund, LP, By: Catalys Pacific Fund GP, LP, its General Partner, By: Catalys Pacific, LLC, its General Partner, By: /s/ Brian Taylor Slingsby, its Managing Director	21 Nov 2025	0001746274

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	MLYS	Common Stock	Sale	$43,350,000	-1,000,000	-11%	$43.35	7,903,838	20 Nov 2025	See Footnote	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents securities held directly by Catalys Pacific Fund, LP. The general partner of Catalys Pacific Fund, LP is Catalys Pacific Fund GP, LP. Brian Taylor Slingsby is the managing partner of Catalys Pacific, LLC, which is the general partner of Catalys Pacific Fund GP, LP. Catalys Pacific, LLC, Catalys Pacific Fund GP, LP and Brian Taylor Slingsby may be deemed to have voting and investment power over the shares held of record by Catalys Pacific Fund, LP. Each of Catalys Pacific, LLC, Catalys Pacific Fund GP, LP and Brian Taylor Slingsby disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

Content

Represents securities held directly by Catalys Pacific Fund, LP. The general partner of Catalys Pacific Fund, LP is Catalys Pacific Fund GP, LP. Brian Taylor Slingsby is the managing partner of Catalys Pacific, LLC, which is the general partner of Catalys Pacific Fund GP, LP. Catalys Pacific, LLC, Catalys Pacific Fund GP, LP and Brian Taylor Slingsby may be deemed to have voting and investment power over the shares held of record by Catalys Pacific Fund, LP. Each of Catalys Pacific, LLC, Catalys Pacific Fund GP, LP and Brian Taylor Slingsby disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein.