| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| LEE ANN L. | Chief Technical Officer | C/O PRIME MEDICINE, INC., 60 FIRST STREET, CAMBRIDGE | /s/ Ryan Brown, attorney-in-fact | 22 May 2025 | 0001723629 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PRME | Common Stock | Purchase | $113K | +100K | $1.13 | 100K | 21 May 2025 | Direct |