Chris Freeman - 05 Dec 2025 Form 4 Insider Report for Guardant Health, Inc. (GH)

Role: Chief Commercial Officer
Signature: /s/ John G. Saia, as attorney-in-fact for Chris Freeman
Issuer symbol: GH
Transactions as of: 05 Dec 2025
Net transactions value: -$3,241,621
Form type: 4
Filing time: 08 Dec 2025, 21:37:36 UTC
Previous filing: 02 Oct 2025
Next filing: 17 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Freeman Chris	Chief Commercial Officer	3100 HANOVER STREET, PALO ALTO	/s/ John G. Saia, as attorney-in-fact for Chris Freeman	08 Dec 2025	0001871615

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GH	Common Stock	Sale	$48,482	-478	-0.83%	$101.43	56,961	05 Dec 2025	Direct	F1
transaction	GH	Common Stock	Sale	$76,116	-744	-1.3%	$102.31	56,217	05 Dec 2025	Direct	F2
transaction	GH	Common Stock	Sale	$38,495	-372	-0.66%	$103.48	55,845	05 Dec 2025	Direct	F3
transaction	GH	Common Stock	Sale	$25,400	-244	-0.44%	$104.10	55,601	05 Dec 2025	Direct	F4
transaction	GH	Common Stock	Sale	$24,312	-228	-0.41%	$106.63	55,373	05 Dec 2025	Direct	F5
transaction	GH	Common Stock	Sale	$414,129	-4,084	-7.4%	$101.40	51,289	05 Dec 2025	Direct	F6
transaction	GH	Common Stock	Sale	$1,221,970	-11,969	-23%	$102.09	39,320	05 Dec 2025	Direct	F7
transaction	GH	Common Stock	Sale	$352,505	-3,414	-8.7%	$103.25	35,906	05 Dec 2025	Direct	F8
transaction	GH	Common Stock	Sale	$681,534	-6,555	-18%	$103.97	29,351	05 Dec 2025	Direct	F9
transaction	GH	Common Stock	Sale	$42,395	-400	-1.4%	$105.99	28,951	05 Dec 2025	Direct	F10
transaction	GH	Common Stock	Sale	$316,283	-2,964	-10%	$106.71	25,987	05 Dec 2025	Direct	F11

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $100.770 to $101.750. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F2	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $101.810 to $102.700. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F3	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $103.005 to $103.860. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F4	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $104.010 to $104.200. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F5	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.450 to $106.735. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F6	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $100.710 to $101.695. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F7	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $101.720 to $102.700. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F8	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $102.720 to $103.710. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F9	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $103.725 to $104.510. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F10	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $105.415 to $106.390. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.
F11	Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.500 to $106.990. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.