| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Smith Michael Alexander | Chief Legal Officer | 700 US HIGHWAY 202/206, BRIDGEWATER | /s/ Michael A. Smith | 05 Nov 2025 | 0001870278 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | INSM | Common Stock | Options Exercise | $644,338 | +27,130 | +49% | $23.75 | 82,032 | 03 Nov 2025 | Direct | F1 |
| transaction | INSM | Common Stock | Sale | $242,915 | -1,342 | -1.6% | $181.01 | 80,690 | 03 Nov 2025 | Direct | F1, F2 |
| transaction | INSM | Common Stock | Sale | $1,385,744 | -7,619 | -9.4% | $181.88 | 73,071 | 03 Nov 2025 | Direct | F1, F3 |
| transaction | INSM | Common Stock | Sale | $782,624 | -4,286 | -5.9% | $182.60 | 68,785 | 03 Nov 2025 | Direct | F1, F4 |
| transaction | INSM | Common Stock | Sale | $741,565 | -4,032 | -5.9% | $183.92 | 64,753 | 03 Nov 2025 | Direct | F1, F5 |
| transaction | INSM | Common Stock | Sale | $599,663 | -3,243 | -5% | $184.91 | 61,510 | 03 Nov 2025 | Direct | F1, F6 |
| transaction | INSM | Common Stock | Sale | $676,041 | -3,636 | -5.9% | $185.93 | 57,874 | 03 Nov 2025 | Direct | F1, F7 |
| transaction | INSM | Common Stock | Sale | $294,200 | -1,572 | -2.7% | $187.15 | 56,302 | 03 Nov 2025 | Direct | F1, F8 |
| transaction | INSM | Common Stock | Sale | $263,158 | -1,400 | -2.5% | $187.97 | 54,902 | 03 Nov 2025 | Direct | F1, F9 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | INSM | Stock Option (right to buy) | Options Exercise | $0 | -27,130 | -100% | $0.000000 | 0 | 03 Nov 2025 | Common Stock | 27,130 | $23.75 | Direct | F1, F10 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. |
| F2 | This is the weighted average sales price representing 1,342 shares sold at prices ranging from $180.29 to $181.19 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F3 | This is the weighted average sales price representing 7,619 shares sold at prices ranging from $181.30 to $182.29 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F4 | This is the weighted average sales price representing 4,286 shares sold at prices ranging from $182.30 to $183.03 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F5 | This is the weighted average sales price representing 4,032 shares sold at prices ranging from $183.49 to $184.48 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F6 | This is the weighted average sales price representing 3,243 shares sold at prices ranging from $184.50 to $185.48 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F7 | This is the weighted average sales price representing 3,636 shares sold at prices ranging from $185.51 to $186.45 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F8 | This is the weighted average sales price representing 1,572 shares sold at prices ranging from $186.61 to $187.53 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F9 | This is the weighted average sales price representing 1,400 shares sold at prices ranging from $187.88 to $188.13 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F10 | The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable. |