| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Kelly Timothy Edwin | Chief Financial Officer | C/O PRAXIS PRECISION MEDICINES, INC., 99 HIGH STREET, 30TH FLOOR, BOSTON | /s/ Alex Nemiroff, as Attorney-in-Fact | 09 Jan 2026 | 0001863297 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PRAX | Common Stock | Tax liability | $40,676 | -139 | -0.56% | $292.63 | 24,524 | 07 Jan 2026 | Direct | F1 |
| Id | Content |
|---|---|
| F1 | Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units. |