Sriram Ryali - 20 Feb 2026 Form 4 Insider Report for Caribou Biosciences, Inc. (CRBU)

Role: Chief Financial Officer
Signature: /s/ Barbara G. McClung, as attorney-in-fact
Issuer symbol: CRBU
Transactions as of: 20 Feb 2026
Net transactions value: $0
Form type: 4
Filing time: 20 Feb 2026, 17:26:37 UTC
Previous filing: 30 Jan 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Ryali Sriram	Chief Financial Officer	C/O CARIBOU BIOSCIENCES, INC., 2929 7TH STREET, SUITE 105, BERKELEY	/s/ Barbara G. McClung, as attorney-in-fact	20 Feb 2026	0001762893

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CRBU	Common Stock	Award	$0	+55,000	+317%	$0.000000	72,360	20 Feb 2026	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	CRBU	Option to purchase Common Stock	Award	$0	+247,500		$0.000000	247,500	20 Feb 2026	Common Stock	247,500	$1.80	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	This reflects restricted stock units ("RSUs") that vest in four equal annual installments beginning on February 20, 2027, subject to the reporting person continuing to provide service to the Issuer through the applicable vesting dates. The RSUs will be settled in stock within 30 days after each vesting date.
F2	1/48 of the total number of shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on February 20, 2030, subject to the reporting person continuing to provide service to the Issuer through each such vesting date.