AmirAli Talasaz - 01 Jan 2026 Form 4 Insider Report for Guardant Health, Inc. (GH)

Role: Co-Chief Executive Officer, Director
Signature: /s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz
Issuer symbol: GH
Transactions as of: 01 Jan 2026
Net transactions value: $0
Form type: 4
Filing time: 17 Mar 2026, 21:57:48 UTC
Previous filing: 22 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Talasaz AmirAli	Co-Chief Executive Officer, Director	3100 HANOVER STREET, PALO ALTO	/s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz	17 Mar 2026	0001753159

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GH	Common Stock	Other		-13,209	-100%	$0.000000^*	0	01 Jan 2026	Direct	F1
transaction	GH	Common Stock	Other		+13,209	+0.63%	$0.000000^*	2,096,311	01 Jan 2026	Shares held by Talasaz and Eskandari 2017 Family Trust	F1
transaction	GH	Common Stock	Options Exercise		+38,283	+1.8%	$0.000000^*	2,134,594	01 Jan 2026	Shares held by Talasaz and Eskandari 2017 Family Trust
transaction	GH	Common Stock	Tax liability		-19,402	-0.91%	$102.14^*	2,115,192	01 Jan 2026	Shares held by Talasaz and Eskandari 2017 Family Trust	F2
transaction	GH	Common Stock	Options Exercise		+26,961	+1.3%	$0.000000^*	2,142,153	13 Mar 2026	Shares held by Talasaz and Eskandari 2017 Family Trust
transaction	GH	Common Stock	Tax liability		-13,664	-0.64%	$85.49^*	2,128,489	13 Mar 2026	Shares held by Talasaz and Eskandari 2017 Family Trust	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GH	Restricted Stock Units	Options Exercise		-38,283	-33%	$0.000000^*	77,727	01 Jan 2026	Common Stock	38,283	$0.000000	Direct	F3, F4
transaction	GH	Performance-Based Restricted Stock Units	Options Exercise		-26,961	-100%	$0.000000^*	0	13 Mar 2026	Common Stock	26,961	$0.000000	Direct	F4
transaction	GH	Restricted Stock Units	Award		+11,268		$0.000000^*	11,268	17 Mar 2026	Common Stock	11,268	$0.000000	Direct	F4, F5
transaction	GH	Restricted Stock Units	Award		+101,409		$0.000000^*	101,409	17 Mar 2026	Common Stock	101,409	$0.000000	Direct	F4, F6

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Reflects changes in form of ownership from direct to indirect due to transfer of shares to Talasaz and Eskandari 2017 Family Trust.
F2	These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability.
F3	This represents a restricted stock unit award granted on March 12, 2025 that vested with respect to 33% of the shares on January 1, 2026 and the remaining 67% of the shares vest in equal quarterly installments over the remaining two-year period thereafter.
F4	Not applicable for Restricted Stock Units.
F5	This represents a restricted stock unit award granted on March 17, 2026 that vests in four equal installments on the last day of each calendar quarter, March 31, 2026, June 30, 2026, September 30, 2026, and December 31, 2026.
F6	This represents a restricted stock unit award granted on March 17, 2026 that vests over a three-year period. 33% of the shares subject to such award vests on January 1, 2027 and the remaining 67% of the shares vest in equal quarterly installments over the remaining two-year period thereafter.