AmirAli Talasaz - 31 Dec 2025 Form 4 Insider Report for Guardant Health, Inc. (GH)

Role: Co-Chief Executive Officer, Director
Signature: /s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz
Issuer symbol: GH
Transactions as of: 31 Dec 2025
Net transactions value: -$1,351,210
Form type: 4
Filing time: 05 Jan 2026, 17:56:36 UTC
Previous filing: 10 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Talasaz AmirAli	Co-Chief Executive Officer, Director	3100 HANOVER STREET, PALO ALTO	/s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz	05 Jan 2026	0001753159

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GH	Common Stock	Options Exercise	$0	+4,815	+0.24%	$0.000000	2,002,689	31 Dec 2025	Direct
transaction	GH	Common Stock	Tax liability	$249,324	-2,441	-0.12%	$102.14	2,000,248	31 Dec 2025	Direct	F1
transaction	GH	Common Stock	Options Exercise	$0	+23,997	+1.2%	$0.000000	2,024,245	01 Jan 2026	Direct
transaction	GH	Common Stock	Tax liability	$1,101,886	-10,788	-0.53%	$102.14	2,013,457	01 Jan 2026	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GH	Restricted Stock Units	Options Exercise	$0	-4,815	-100%	$0.000000	0	31 Dec 2025	Common Stock	4,815	$0.000000	Direct	F2, F3
transaction	GH	Restricted Stock Units	Options Exercise	$0	-23,997	-20%	$0.000000	95,989	01 Jan 2026	Common Stock	23,997	$0.000000	Direct	F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability.
F2	This represents a restricted stock unit award granted on March 12, 2025 that vests in four equal installments on the last day of each calendar quarter, March 31, 2025, June 30, 2025, September 30, 2025, and December 31, 2025.
F3	Not applicable for Restricted Stock Units.
F4	This represents a restricted stock unit award granted on March 18, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter.