John G. Saia - 01 Sep 2025 Form 4 Insider Report for Guardant Health, Inc. (GH)

Role: Chief Legal Officer
Signature: /s/ John G. Saia
Issuer symbol: GH
Transactions as of: 01 Sep 2025
Net transactions value: -$9,371
Form type: 4
Filing time: 03 Sep 2025, 18:47:28 UTC
Previous filing: 02 Jul 2025
Next filing: 17 Sep 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Saia John G.	Chief Legal Officer	3100 HANOVER STREET, PALO ALTO	/s/ John G. Saia	03 Sep 2025	0001737840

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GH	Common Stock	Options Exercise	$0	+264	+0.59%	$0.000000	45,087	01 Sep 2025	Direct
transaction	GH	Common Stock	Tax liability	$9,371	-139	-0.31%	$67.42	44,948	01 Sep 2025	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GH	Restricted Stock Units	Options Exercise	$0	-264	-100%	$0.000000	0	01 Sep 2025	Common Stock	264	$0.000000	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Not applicable for Restricted Stock Units.
F2	The restricted stock unit award was granted on November 2, 2021, and vested 25% of the shares subject to such award on September 1, 2022. The remaining 75% of the shares subject to such award vests in equal installments on each quarterly anniversary of September 1, 2022 during the three-year period thereafter.