| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Garg Pushkal | EVP Chief R&D | 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE | By: Brett Budzinski, Attorney-in-Fact For: Pushkal Garg | 06 Mar 2026 | 0001829252 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Sale | $33,817 | -106 | -0.45% | $319.03 | 23,300 | 04 Mar 2026 | Direct | F1, F2 |
| transaction | ALNY | Common Stock | Sale | $32,641 | -102 | -0.44% | $320.01 | 23,198 | 04 Mar 2026 | Direct | F1, F3 |
| transaction | ALNY | Common Stock | Sale | $68,974 | -215 | -0.93% | $320.81 | 22,983 | 04 Mar 2026 | Direct | F1, F4 |
| transaction | ALNY | Common Stock | Sale | $93,006 | -289 | -1.3% | $321.82 | 22,694 | 04 Mar 2026 | Direct | F1, F5 |
| transaction | ALNY | Common Stock | Sale | $113,054 | -350 | -1.5% | $323.01 | 22,344 | 04 Mar 2026 | Direct | F1, F6 |
| transaction | ALNY | Common Stock | Sale | $248,385 | -767 | -3.4% | $323.84 | 21,577 | 04 Mar 2026 | Direct | F1, F7 |
| transaction | ALNY | Common Stock | Sale | $88,367 | -272 | -1.3% | $324.88 | 21,305 | 04 Mar 2026 | Direct | F1, F8 |
| transaction | ALNY | Common Stock | Sale | $67,739 | -208 | -0.98% | $325.67 | 21,097 | 04 Mar 2026 | Direct | F1, F9 |
| transaction | ALNY | Common Stock | Sale | $210,804 | -654 | -3.1% | $322.33 | 20,443 | 05 Mar 2026 | Direct | F10, F11 |
| transaction | ALNY | Common Stock | Sale | $239,427 | -740 | -3.6% | $323.55 | 19,703 | 05 Mar 2026 | Direct | F10, F12 |
| transaction | ALNY | Common Stock | Sale | $165,541 | -510 | -2.6% | $324.59 | 19,193 | 05 Mar 2026 | Direct | F10, F13 |
| transaction | ALNY | Common Stock | Sale | $163,040 | -500 | -2.6% | $326.08 | 18,693 | 05 Mar 2026 | Direct | F10, F14 |
| holding | ALNY | Common Stock | 431 | 04 Mar 2026 | by Managed Account | F15 | |||||
| holding | ALNY | Common Stock | 250 | 04 Mar 2026 | by Trust | F16 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations upon the vesting of restricted stock units. |
| F2 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $318.27 to $319.27. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F3 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $319.28 to $320.28. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F4 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $320.33 to $321.33. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F5 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $321.34 to $322.31. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F6 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $322.36 to $323.36. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F7 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $323.38 to $324.35. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F8 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $324.39 to $325.38. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F9 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $325.40 to $326.21. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F10 | This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on November 20, 2025. |
| F11 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $322.03 to $322.96. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F12 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $323.09 to $324.08. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F13 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $324.26 to $325.20. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F14 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $325.67 to $326.40. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F15 | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. |
| F16 | Represents shares held in trust, of which the Reporting Persons spouse is co-trustee. The Reporting Person disclaims beneficial ownership of these shares, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. |