| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Tanguler Tolga | EVP, Chief Commercial Officer | 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE | By: Brett Budzinski, Attorney-in-Fact For: Tolga Tanguler | 02 Mar 2026 | 0001849458 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Options Exercise | $0 | +1,666 | +5.2% | $0.000000 | 33,435 | 27 Feb 2026 | Direct |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Restricted Stock Units | Options Exercise | $0 | -1,666 | -100% | $0.000000 | 0 | 27 Feb 2026 | Common Stock | 1,666 | Direct | F1, F2, F3 |
| Id | Content |
|---|---|
| F1 | These shares are represented by restricted stock units (RSUs) granted under the Amended and Restated 2018 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock. |
| F2 | On February 27, 2023, the reporting person was granted 5,000 restricted stock units that vest ratably on each of the first, second and third anniversaries of the Grant Date. On February 27, 2026, the third and final tranche of restricted stock units from the February 27, 2023 grant vested and was released, as reported on this Form 4. |
| F3 | The restricted stock units vest ratably in three installments, with one third vesting on each of the first, second and third anniversaries of the grant date. |