| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Fitzgerald Kevin Joseph | CSO & EVP, Head of Research | 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE | By: Brett Budzinski, Attorney-in-Fact For: Kevin Fitzgerald | 25 Feb 2026 | 0001886431 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Award | $0 | +158 | +0.74% | $0.000000 | 21,422 | 23 Feb 2026 | Direct | F1 |
| holding | ALNY | Common Stock | 537 | 23 Feb 2026 | by Managed Account | F2 |
| Id | Content |
|---|---|
| F1 | On February 23, 2026, the People, Culture, and Compensation Committee of the issuer approved the issuance of shares of Company common stock having an aggregate value of USD $100,000 to each employee who completes 20 consecutive years of employment. The shares issued and reported here on Form 4, net of the minimum statutory tax liability, were issued to the reporting person in recognition of 20 years of continuous employment on December 5, 2025. |
| F2 | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. |