| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Garg Pushkal | EVP Chief R&D | 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE | By: Brett Budzinski, Attorney-in-Fact For: Pushkal Garg | 17 Feb 2026 | 0001829252 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Award | $0 | +4,579 | +20% | $0.000000 | 27,090 | 12 Feb 2026 | Direct | F1 |
| transaction | ALNY | Common Stock | Sale | $695,201 | -2,242 | -8.3% | $310.08 | 24,848 | 13 Feb 2026 | Direct | F2, F3 |
| holding | ALNY | Common Stock | 431 | 12 Feb 2026 | by Managed Account | F4 | |||||
| holding | ALNY | Common Stock | 250 | 12 Feb 2026 | by Trust | F5 |
| Id | Content |
|---|---|
| F1 | On February 27, 2023, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of forty (40) percent of the shares subject to the PSU based on the issuer publicly reporting the achievement of non-GAAP operating income for fiscal year 2025 on February 12, 2026, as determined by the People, Culture and Compensation Committee of the Issuer Board of Directors. |
| F2 | Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement to cover minimum statutory tax withholding obligations. |
| F3 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $302.55 to $314.60. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F4 | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. |
| F5 | Represents shares held in trust, of which the Reporting Persons spouse is co-trustee. The Reporting Person disclaims beneficial ownership of these shares, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. |