| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Garg Pushkal | EVP Chief R&D | 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE | By: Brett Budzinski, Attorney-in-Fact For: Pushkal Garg | 19 Aug 2025 | 0001829252 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | ALNY | Common Stock | Award | $0 | +2.85K | +14.1% | $0.00 | 23.1K | 15 Aug 2025 | Direct | F1 |
| transaction | ALNY | Common Stock | Sale | -$17.5K | -39 | -0.17% | $447.98 | 23K | 18 Aug 2025 | Direct | F2, F3 |
| transaction | ALNY | Common Stock | Sale | -$40.5K | -90 | -0.39% | $449.92 | 22.9K | 18 Aug 2025 | Direct | F2, F4 |
| transaction | ALNY | Common Stock | Sale | -$17.6K | -39 | -0.17% | $450.92 | 22.9K | 18 Aug 2025 | Direct | F2, F5 |
| transaction | ALNY | Common Stock | Sale | -$46.6K | -103 | -0.45% | $451.99 | 22.8K | 18 Aug 2025 | Direct | F2, F6 |
| transaction | ALNY | Common Stock | Sale | -$149K | -329 | -1.44% | $452.96 | 22.5K | 18 Aug 2025 | Direct | F2, F7 |
| transaction | ALNY | Common Stock | Sale | -$247K | -543 | -2.42% | $454.04 | 21.9K | 18 Aug 2025 | Direct | F2, F8 |
| transaction | ALNY | Common Stock | Sale | -$110K | -241 | -1.1% | $454.84 | 21.7K | 18 Aug 2025 | Direct | F2, F9 |
| transaction | ALNY | Common Stock | Sale | -$5.47K | -12 | -0.06% | $455.82 | 21.7K | 18 Aug 2025 | Direct | F2, F10 |
| transaction | ALNY | Common Stock | Sale | -$126K | -276 | -1.27% | $455.41 | 21.4K | 19 Aug 2025 | Direct | F11, F12 |
| transaction | ALNY | Common Stock | Sale | -$155K | -338 | -1.58% | $457.26 | 21.1K | 19 Aug 2025 | Direct | F11, F13 |
| transaction | ALNY | Common Stock | Sale | -$106K | -231 | -1.1% | $458.27 | 20.8K | 19 Aug 2025 | Direct | F11, F14 |
| transaction | ALNY | Common Stock | Sale | -$119K | -260 | -1.25% | $459.59 | 20.6K | 19 Aug 2025 | Direct | F11, F15 |
| transaction | ALNY | Common Stock | Sale | -$141K | -305 | -1.48% | $461.01 | 20.3K | 19 Aug 2025 | Direct | F11, F16 |
| transaction | ALNY | Common Stock | Sale | -$20.8K | -45 | -0.22% | $461.74 | 20.2K | 19 Aug 2025 | Direct | F11 |
| holding | ALNY | Common Stock | 431 | 15 Aug 2025 | by Managed Account | F17 | |||||
| holding | ALNY | Common Stock | 250 | 15 Aug 2025 | by Trust | F18 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | On March 1, 2024, the reporting person was granted a performance-based stock unit (PSU) under the 2018 Stock Incentive Plan. The shares subject to the PSU vest based on the achievement of three specified performance measures. The shares reported were issued to the reporting person upon vesting of thirty (30) percent of the shares subject to the PSU based on the achievement of a clinical milestone, as determined by The People, Culture and Compensation Committee of the Issuer Board of Directors on August 15, 2025. |
| F2 | Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of a tranche of restricted stock units granted to the reporting person on March 1, 2024. |
| F3 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $447.53 to $448.45. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F4 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $449.21 to $450.16. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F5 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $450.42 to $451.39. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F6 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $451.48 to $452.48. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F7 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $452.49 to $453.49. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F8 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $453.50 to $454.45. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F9 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $454.58 to $455.55. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F10 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $455.65 to $456.00. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F11 | All transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on September 11, 2024. |
| F12 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $454.94 to $455.77. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F13 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $456.64 to $457.51. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F14 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $457.76 to $458.65. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F15 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $459.20 to $460.01. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F16 | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $460.60 to $461.44. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. |
| F17 | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. |
| F18 | Represents shares held in trust, of which the Reporting Persons spouse is co-trustee. The Reporting Person disclaims beneficial ownership of these shares, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. |