Yvonne Greenstreet - 30 May 2025 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Signature
By: Brett Budzinski, Attorney-in-Fact For: Yvonne Greenstreet
Issuer symbol
ALNY
Transactions as of
30 May 2025
Net transactions value
-$9,496,577
Form type
4
Filing time
03 Jun 2025, 16:10:42 UTC
Previous filing
19 May 2025
Next filing
19 Aug 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Greenstreet Yvonne Chief Executive Officer, Director 675 WEST KENDALL STREET, HENRI A. TERMEER SQUARE, CAMBRIDGE By: Brett Budzinski, Attorney-in-Fact For: Yvonne Greenstreet 03 Jun 2025 0001446125

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction ALNY Common Stock Options Exercise $1,439,210 +12,081 +25% $119.13 61,029 30 May 2025 Direct F1
transaction ALNY Common Stock Options Exercise $2,308,940 +19,559 +32% $118.05 80,588 30 May 2025 Direct F1
transaction ALNY Common Stock Sale $7,742,576 -25,469 -32% $304.00 55,119 30 May 2025 Direct F1
transaction ALNY Common Stock Sale $1,888,326 -6,171 -11% $306.00 48,948 30 May 2025 Direct F1
transaction ALNY Common Stock Options Exercise $1,439,090 +12,080 +25% $119.13 61,028 02 Jun 2025 Direct F1
transaction ALNY Common Stock Options Exercise $851,967 +7,217 +12% $118.05 68,245 02 Jun 2025 Direct F1
transaction ALNY Common Stock Sale $5,904,882 -19,297 -28% $306.00 48,948 02 Jun 2025 Direct F1
holding ALNY Common Stock 407 30 May 2025 by Managed Account F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction ALNY Stock Option (right to buy) Options Exercise $0 -19,559 -71% $0.000000 8,064 30 May 2025 Common Stock 19,559 $118.05 Direct F1, F3
transaction ALNY Stock Option (right to buy) Options Exercise $0 -7,217 -89% $0.000000 847 02 Jun 2025 Common Stock 7,217 $118.05 Direct F1, F3
transaction ALNY Stock Option (right to buy) Options Exercise $0 -12,081 -48% $0.000000 12,919 30 May 2025 Common Stock 12,081 $119.13 Direct F1, F4
transaction ALNY Stock Option (right to buy) Options Exercise $0 -12,080 -94% $0.000000 839 02 Jun 2025 Common Stock 12,080 $119.13 Direct F1, F4
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 The transactions reported on this Form 4 were made pursuant to a Rule 10b5-1(c) trading plan adopted by the reporting person on September 12, 2024.
F2 Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program.
F3 This stock option was fully vested and exercisable as of February 26, 2024.
F4 This stock option was fully vested and exercisable as of December 1, 2021.