Indrani Lall Franchini - 01 Feb 2023 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role: EVP, CLO & Secretary
Signature: By: /s/ Cynthia L Anderson, Attorney-in-Fact For: Indrani Franchini
Issuer symbol: ALNY
Transactions as of: 01 Feb 2023
Net transactions value: -$378,563
Form type: 4
Filing time: 03 Feb 2023, 16:46:11 UTC
Previous filing: 09 Feb 2022
Next filing: 01 Mar 2023
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ALNY	Common Stock	Options Exercise	$0	+5,175		$0.000000	5,175	01 Feb 2023	Direct
transaction	ALNY	Common Stock	Sale	$17,246	-77	-1.5%	$223.97	5,098	02 Feb 2023	Direct	F1, F2
transaction	ALNY	Common Stock	Sale	$227,381	-1,007	-20%	$225.80	4,091	02 Feb 2023	Direct	F1, F3
transaction	ALNY	Common Stock	Sale	$132,799	-586	-14%	$226.62	3,505	02 Feb 2023	Direct	F1, F4
transaction	ALNY	Common Stock	Sale	$1,137	-5	-0.14%	$227.38	3,500	02 Feb 2023	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	ALNY	Restricted Stock Units	Options Exercise	$0	-5,175	-33%	$0.000000	10,350	01 Feb 2023	Common Stock	5,175		Direct	F5, F6

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units reported in this form.
F2	The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $223.42 to $224.25. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F3	The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $225.21 to $226.20. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F4	The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $226.23 to $227.12. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
F5	Each restricted stock unit represents a contingent right to receive one share of ALNY common stock.
F6	On February 1, 2022 the reporting person received 15,525 restricted stock units that vest ratably on each of the first, second and third anniversaries of the Grant Date. On February 1, 2023 the first third vested and released as reported on this Form 4.