Tolga Tanguler - Feb 1, 2022 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role: EVP, Chief Commercial Officer
Signature: By: /s/ Mary Beth DeLena, Attorney-in-Fact For: Tolga Tanguler
Stock symbol: ALNY
Transactions as of: Feb 1, 2022
Transactions value $: -$219,609
Form type: 4
Date filed: 2/3/2022, 03:10 PM
Next filing: Feb 25, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ALNY	Common Stock	Options Exercise	$0	+5.03K		$0.00	5.03K	Feb 1, 2022	Direct
transaction	ALNY	Common Stock	Tax liability	-$220K	-1.52K	-30.2%	$144.67	3.51K	Feb 2, 2022	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	ALNY	Restricted Stock Units	Options Exercise	$0	-5.03K	-50%	$0.00	5.03K	Feb 1, 2022	Common Stock	5.03K	$0.00	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting event.
F2	On February 1, 2021 the reporting person received 10,051 restricted stock units, one-half of which vested on the first anniversary of the grant date, and one-half of which will vest on the second anniversary of the grant date.