Pushkal Garg - Dec 31, 2021 Form 3 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role: CMO & EVP Dev & Med Affairs
Signature: By: /s/ Mary Beth DeLena, Attorney-in-Fact For: Pushkal Garg
Stock symbol: ALNY
Transactions as of: Dec 31, 2021
Transactions value $: $0
Form type: 3
Date filed: 1/4/2022, 03:03 PM
Previous filing: Jun 17, 2021
Next filing: Feb 25, 2022

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
holding	ALNY	Common Stock						11.2K	Dec 31, 2021	Direct
holding	ALNY	Common Stock						431	Dec 31, 2021	by Managed Account	F1
holding	ALNY	Common Stock						250	Dec 31, 2021	by Trust	F2

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
holding	ALNY	Performance Stock Option 2014 (right to buy)							Dec 31, 2021	Common Stock	2.5K	$96.45	Direct
holding	ALNY	Performance Stock Option 2015 (right to buy)							Dec 31, 2021	Common Stock	25K	$88.95	Direct
holding	ALNY	Performance Stock Option 2017 (right to buy)							Dec 31, 2021	Common Stock	13.8K	$119.13	Direct
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	5.45K	$42.22	Direct	F3
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	25K	$85.00	Direct	F3
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	23.9K	$88.95	Direct	F3
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	2.5K	$96.45	Direct	F3
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	26.1K	$118.05	Direct	F3
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	13.8K	$119.13	Direct	F4
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	23.2K	$151.59	Direct	F3
holding	ALNY	Stock Option (right to buy)							Dec 31, 2021	Common Stock	13.4K	$169.58	Direct	F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.
F2	Represents shares held in trust, of which the reporting persons spouse is co-trustee. The reporting person disclaims beneficial ownership of these shares, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
F3	The stock option vests as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.
F4	The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to the remaining shares ratably at the end of each three-month period thereafter over the following thirty-three (33) months.