JOHN MARAGANORE - 13 May 2021 Form 4 Insider Report for ALNYLAM PHARMACEUTICALS, INC. (ALNY)

Role: Chief Executive Officer, Director
Signature: By: /s/ Mary Beth DeLena, Attorney-in-Fact For: John M. Maraganore
Issuer symbol: ALNY
Transactions as of: 13 May 2021
Net transactions value: -$4,202,474
Form type: 4
Filing time: 17 May 2021, 19:25:53 UTC
Next filing: 24 May 2021
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ALNY	Common Stock	Options Exercise	$241,251	+33,979	+16%	$7.10^*	248,744	13 May 2021	Direct	F1
transaction	ALNY	Common Stock	Sale	$386,824	-3,015	-1.2%	$128.30	245,729	13 May 2021	Direct	F1, F2
transaction	ALNY	Common Stock	Sale	$583,492	-4,512	-1.8%	$129.32	241,217	13 May 2021	Direct	F1, F3
transaction	ALNY	Common Stock	Sale	$1,188,831	-9,121	-3.8%	$130.34	232,096	13 May 2021	Direct	F1, F4
transaction	ALNY	Common Stock	Sale	$1,469,610	-11,203	-4.8%	$131.18	220,893	13 May 2021	Direct	F1, F5
transaction	ALNY	Common Stock	Sale	$460,606	-3,481	-1.6%	$132.32	217,412	13 May 2021	Direct	F1, F6
transaction	ALNY	Common Stock	Sale	$216,901	-1,624	-0.75%	$133.56	215,788	13 May 2021	Direct	F1, F7
transaction	ALNY	Common Stock	Sale	$137,461	-1,023	-0.47%	$134.37	214,765	13 May 2021	Direct	F1, F8
holding	ALNY	Common Stock						3,133	13 May 2021	by Managed Account	F9

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	ALNY	Stock Option (right to buy)	Options Exercise	$0	-33,979	-33%	$0.000000	67,957	13 May 2021	Common Stock	33,979	$7.10	Direct	F1, F10

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	All sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 9, 2020. The 33,979 options exercised and sold by the reporting person were due to expire on November 30, 2021.
F2	Sale prices ranged from $127.73 to $128.73.
F3	Sale prices ranged from $128.80 to $129.77.
F4	Sale prices ranged from $129.81 to $130.81.
F5	Sale prices ranged from $130.82 to $131.81.
F6	Sale prices ranged from $131.84 to $132.78.
F7	Sale prices ranged from $132.97 to $133.77.
F8	Sale prices ranged from $134.11 to $134.40.
F9	Reflects shares of ALNY common stock acquired by the reporting person under the ALNY 401(k) plan as a result of the ALNY 401(k) matching contribution program.
F10	The stock option vested as to 25% of the shares on the 1st anniversary of the date of the stock option grant and as to an additional 6.25% of the shares each successive three month period thereafter.