| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Schuth Alexander O. | COFO and Secretary | C/O DENALI THERAPEUTICS INC., 161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO | /s/ Tyler Nielsen, by power of attorney | 08 Jan 2026 | 0001724311 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Common Stock | Sale | $284,097 | -17,218 | -5.7% | $16.50 | 282,828 | 06 Jan 2026 | Direct | F1, F2 |
| holding | DNLI | Common Stock | 523,749 | 06 Jan 2026 | See footnote | F3 |
| Id | Content |
|---|---|
| F1 | Shares sold to satisfy the tax obligations by the Reporting Person in connection with the settlement of previously vested RSUs. |
| F2 | Includes 141,100 Unvested RSUs. |
| F3 | The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee. |