| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Schuth Alexander O. | COFO and Secretary | C/O DENALI THERAPEUTICS INC., 161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO | /s/ Tyler Nielsen, by power of attorney | 14 Aug 2025 | 0001724311 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Common Stock | Sale | $39,884 | -2,937 | -1.2% | $13.58 | 242,346 | 12 Aug 2025 | Direct | F1, F2, F3, F4 |
| holding | DNLI | Common Stock | 523,749 | 12 Aug 2025 | See footnote | F5 |
| Id | Content |
|---|---|
| F1 | Shares sold to satisfy the tax obligations by the Reporting Person in connection with the settlement of previously vested restricted stock units. |
| F2 | The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $13.35 to $13.58 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. |
| F3 | Includes 128,405 Unvested RSUs. |
| F4 | Includes 975 shares acquired under the ESPP Purchase on June 2, 2025. |
| F5 | The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee. |