| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Ho Carole | Chief Medical Officer | C/O DENALI THERAPEUTICS INC., 161 OYSTER POINT BLVD., SOUTH SAN FRANCISCO | /s/ Tyler Nielsen, by power of attorney | 07 Aug 2025 | 0001724605 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Common Stock | Options Exercise | $30,365 | +44,655 | +25% | $0.6800 | 220,328 | 05 Aug 2025 | Direct | F1 |
| holding | DNLI | Common Stock | 183,219 | 05 Aug 2025 | See footnote | F2 | |||||
| holding | DNLI | Common Stock | 25,000 | 05 Aug 2025 | See footnote | F3 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | DNLI | Stock Option (right to buy) | Options Exercise | $0 | -44,655 | -42% | $0.000000 | 62,500 | 05 Aug 2025 | Common Stock | 44,655 | $0.6800 | Direct | F4 |
| Id | Content |
|---|---|
| F1 | Includes 134,030 Unvested RSUs. |
| F2 | The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee. |
| F3 | The shares are held of record by The Rohatgi-Ho Irrevocable GST Trust for the benefit of the Reporting Person's children. |
| F4 | The vesting of the shares subject to the option are contingent upon the achievement of certain performance metrics. 50% of the shares subject to the option vested on March 3, 2021, and 50% of the shares subject to the option will vest on the date the closing price of Issuer's Common Stock equals or exceeds $80.00 per share on NASDAQ for 90 consecutive trading days. |