Schuth Alexander O. - 07 Oct 2022 Form 4 Insider Report for Denali Therapeutics Inc. (DNLI)

Role: COFO and Secretary
Signature: /s/ Tyler Nielsen, by power of attorney
Issuer symbol: DNLI
Transactions as of: 07 Oct 2022
Net transactions value: +$13,600
Form type: 4
Filing time: 12 Oct 2022, 16:05:35 UTC
Previous filing: 23 Aug 2022
Next filing: 09 Jan 2023
SEC: View on sec.gov

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	DNLI	Common Stock	Options Exercise	$13,600	+20,000	+4.3%	$0.6800^*	487,471	07 Oct 2022	See footnote	F1, F2
holding	DNLI	Common Stock						116,458	07 Oct 2022	Direct	F3

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	DNLI	Stock Option (right to buy)	Options Exercise	$0	-20,000	-8.3%	$0.000000	220,078	07 Oct 2022	Common Stock	20,000	$0.6800	Direct	F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Exercised shares were issued to the Schuth Family Trust.
F2	The shares are held of record by The Schuth Family Trust U/A DTD 06/05/2017, for which the Reporting Person serves as trustee.
F3	Includes 104,822 restricted stock units
F4	The vesting of the shares subject to the option is contingent upon the achievement of certain performance metrics. 50% of the shares subject to the option vested on the date the closing price of Issuer's Common Stock equaled or exceeded $40.00 per share on NASDAQ for 90 consecutive trading days, beginning no earlier than June 10, 2018; and 50% of the shares subject to the option vest on the date the closing price of Issuer's Common Stock equals or exceeds $80.00 per share on NASDAQ for 90 consecutive trading days, beginning no earlier than June 10, 2018.