Michael Brian Bell - 15 Dec 2025 Form 4 Insider Report for Guardant Health, Inc. (GH)

Role: Chief Financial Officer
Signature: /s/ John G. Saia, as attorney-in-fact for Michael Brian Bell
Issuer symbol: GH
Transactions as of: 15 Dec 2025
Net transactions value: -$170,330
Form type: 4
Filing time: 17 Dec 2025, 19:17:11 UTC
Previous filing: 08 Dec 2025
Next filing: 05 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Bell Michael Brian	Chief Financial Officer	3100 HANOVER STREET, PALO ALTO	/s/ John G. Saia, as attorney-in-fact for Michael Brian Bell	17 Dec 2025	0001702824

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	GH	Common Stock	Options Exercise	$0	+1,233	+4.4%	$0.000000	29,285	15 Dec 2025	Direct
transaction	GH	Common Stock	Options Exercise	$0	+2,039	+7%	$0.000000	31,324	15 Dec 2025	Direct
transaction	GH	Common Stock	Tax liability	$170,330	-1,659	-5.3%	$102.67	29,665	15 Dec 2025	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	GH	Restricted Stock Units	Options Exercise	$0	-1,233	-50%	$0.000000	1,233	15 Dec 2025	Common Stock	1,233	$0.000000	Direct	F2, F3
transaction	GH	Restricted Stock Units	Options Exercise	$0	-2,039	-33%	$0.000000	4,078	15 Dec 2025	Common Stock	2,039	$0.000000	Direct	F3, F4

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability.
F2	This represents a restricted stock unit award granted on May 9, 2022 that vests over a four-year period. 25% of the shares subject to such award vested on March 15, 2023 and the remaining 75% of the shares vests in equal quarterly installments over the remaining three-year period thereafter.
F3	Not applicable for Restricted Stock Units.
F4	This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter.