| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Arbuckle Stuart A | Director | C/O PRAXIS PRECISION MEDICINES, INC., 99 HIGH STREET, 30TH FLOOR, BOSTON | /s/ Alex Nemiroff, as Attorney-in-Fact | 10 Feb 2026 | 0001557290 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PRAX | Common Stock | Award | $0 | +688 | $0.000000 | 688 | 06 Feb 2026 | Direct | F1 | |
| transaction | PRAX | Common Stock | Award | $0 | +478 | +69% | $0.000000 | 1,166 | 06 Feb 2026 | Direct | F2 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | PRAX | Stock Option (Right to Buy) | Award | $0 | +224 | $0.000000 | 224 | 06 Feb 2026 | Common Stock | 224 | $319.57 | Direct | F3 |
| Id | Content |
|---|---|
| F1 | Mr. Arbuckle was awarded 688 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in two equal annual installments occurring on the first two anniversaries of January 8, 2026. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance. |
| F2 | Mr. Arbuckle was awarded 478 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 26, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance. |
| F3 | The shares subject to this option shall vest in equal monthly installments occurring on the 26th day of each month, with the first such installment occurring on February 26, 2026 and the final such installment occurring on the earlier of (i) June 26, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders. |