Marcio Souza - 08 Jan 2026 Form 4 Insider Report for Praxis Precision Medicines, Inc. (PRAX)

Role: Chief Executive Officer, Director
Signature: /s/ Alex Nemiroff, as Attorney-in-Fact
Issuer symbol: PRAX
Transactions as of: 08 Jan 2026
Net transactions value: -$1,226,489
Form type: 4
Filing time: 12 Jan 2026, 17:48:23 UTC
Previous filing: 09 Jan 2026
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Souza Marcio	Chief Executive Officer, Director	C/O PRAXIS PRECISION MEDICINES, INC., 99 HIGH STREET, 30TH FLOOR, BOSTON	/s/ Alex Nemiroff, as Attorney-in-Fact	12 Jan 2026	0001707657

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	PRAX	Common Stock	Award	$0	+27,640	+52%	$0.000000	81,142	08 Jan 2026	Direct	F1
transaction	PRAX	Common Stock	Tax liability	$1,226,489	-4,252	-5.2%	$288.45	76,890	10 Jan 2026	Direct	F2
holding	PRAX	Common Stock						2,600	08 Jan 2026	Held by spouse

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	PRAX	Stock Option (Right to Buy)	Award	$0	+22,110		$0.000000	22,110	08 Jan 2026	Common Stock	22,110	$294.38	Direct	F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Mr. Souza was awarded 27,640 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. The restricted stock units vest in equal annual installments over a four-year period beginning on the one-year anniversary of the vesting commencement date of January 8, 2026. The restricted stock units may be settled only by delivering shares of the Issuer's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.
F2	Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.
F3	The shares underlying this stock option vest over a four-year period, with 25% vesting on January 8, 2027 and the remaining 75% vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.