Jonathan Watkins - 28 May 2025 Form 4 Insider Report for SmartKem, Inc. (SMTK)

Role: Chief Operating Officer
Signature: /s/ Barbra Keck, attorney-in-fact for Jonathan Watkins
Issuer symbol: SMTK
Transactions as of: 28 May 2025
Net transactions value: $0
Form type: 4
Filing time: 28 May 2025, 21:00:16 UTC
Previous filing: 10 Mar 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Watkins Jonathan	Chief Operating Officer	C/O SMARTKEM, MANCHESTER TECHNOLOGY CTR, HEXAGON TOWER DELAUNAYS ROAD, BLACKLEY, MANCHESTER, UNITED KINGDOM	/s/ Barbra Keck, attorney-in-fact for Jonathan Watkins	28 May 2025	0002058845

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SMTK	Stock Option (right to Buy)	Award	$0	+131,745		$0.000000	131,745	28 May 2025	Common Stock	131,745	$2.51	Direct	F1, F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The stock option grant was approved by the Compensation Committee of SmartKem, Inc.'s (the "Company") board of directors on April 15, 2025, subject to stockholder approval of an Amendment to the SmartKem, Inc. 2021 Equity Incentive Plan (the "Amendment"). The Company's stockholders approved the Amendment on May 28, 2025.
F2	The option vests as follows: 25% on the date of grant with the remaining shares to vest in equal monthly installments over a period of 36 months commencing on May 15, 2025 and on the 15th date of each month thereafter.