| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| ENRIGHT PATRICK G | Director, 10%+ Owner | C/O LONGITUDE CAPITAL, 2740 SAND HILL ROAD, SECOND FLOOR, MENLO PARK | /s/ Michael Greco, Attorney-in-Fact | 05 Feb 2026 | 0001253886 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | MANE | Common Stock | Conversion of derivative security | +1,236,631 | 1,236,631 | 05 Feb 2026 | See Footnote | F1, F2 | |||
| transaction | MANE | Common Stock | Conversion of derivative security | +1,171,121 | +95% | 2,407,752 | 05 Feb 2026 | See Footnote | F2, F3 | ||
| transaction | MANE | Common Stock | Conversion of derivative security | +1,171,121 | 1,171,121 | 05 Feb 2026 | See Footnote | F3, F4 | |||
| transaction | MANE | Common Stock | Purchase | $3,274,999 | +192,647 | +8% | $17.00 | 2,600,399 | 05 Feb 2026 | See Footnote | F2 |
| transaction | MANE | Common Stock | Purchase | $15,000,001 | +882,353 | +75% | $17.00 | 2,053,474 | 05 Feb 2026 | See Footnote | F4 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | MANE | Series B Convertible Preferred Stock | Conversion of derivative security | -1,236,631 | -100% | 0 | 05 Feb 2026 | Common Stock | 1,236,631 | See Footnote | F1 | |||
| transaction | MANE | Series C Convertible Preferred Stock | Conversion of derivative security | -1,171,121 | -100% | 0 | 05 Feb 2026 | Common Stock | 1,171,121 | See Footnote | F3 | |||
| transaction | MANE | Series C Convertible Preferred Stock | Conversion of derivative security | -1,171,121 | -100% | 0 | 05 Feb 2026 | Common Stock | 1,171,121 | See Footnote | F3 | |||
| transaction | MANE | Stock Option (Right to Buy) | Award | $0 | +45,131 | $0.000000 | 45,131 | 03 Feb 2026 | Common Stock | 45,131 | $17.00 | Direct | F5 |
| Id | Content |
|---|---|
| F1 | On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date. |
| F2 | These shares are held by Longitude Venture Partners V, L.P. ("LVPV"). Longitude Capital Partners V, LLC ("LCPV"), is the general partner of LVPV and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and the Reporting Person, a member of the board of directors of the Issuer, are the managing members of LCPV, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of LCPV, Ms. Tammenoms Bakker and the Reporting Person disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein. |
| F3 | On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date. |
| F4 | These shares are held by Longitude 103.8 East, L.P. ("L103"). Longitude 103.8 East Partners, LLC ("L103P") is the general partner of L103 and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and the Reporting Person, a member of the board of directors of the Issuer, are the managing members of L103P, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of L103P, Ms. Tammenoms Bakker and the Reporting Person disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein. |
| F5 | This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date. |