| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Lewis William | Chair and CEO, Director | 700 US HIGHWAY 202/206, BRIDGEWATER | /s/ William Lewis, by Michael A. Smith as Attorney-in-fact | 19 Dec 2025 | 0001402051 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | INSM | Common Stock | Options Exercise | $76.2K | +4.44K | +1.46% | $17.16 | 308K | 18 Dec 2025 | Direct | F1 |
| transaction | INSM | Common Stock | Options Exercise | $191K | +6.26K | +2.03% | $30.46 | 315K | 18 Dec 2025 | Direct | F1 |
| transaction | INSM | Common Stock | Sale | -$56.8K | -350 | -0.11% | $162.26 | 314K | 18 Dec 2025 | Direct | F1, F2 |
| transaction | INSM | Common Stock | Sale | -$239K | -1.47K | -0.47% | $163.19 | 313K | 18 Dec 2025 | Direct | F1, F3 |
| transaction | INSM | Common Stock | Sale | -$73.4K | -447 | -0.14% | $164.24 | 312K | 18 Dec 2025 | Direct | F1, F4 |
| transaction | INSM | Common Stock | Sale | -$115K | -697 | -0.22% | $165.21 | 312K | 18 Dec 2025 | Direct | F1, F5 |
| transaction | INSM | Common Stock | Sale | -$297K | -1.78K | -0.57% | $166.60 | 310K | 18 Dec 2025 | Direct | F1, F6 |
| transaction | INSM | Common Stock | Sale | -$239K | -1.43K | -0.46% | $167.29 | 308K | 18 Dec 2025 | Direct | F1, F7 |
| transaction | INSM | Common Stock | Sale | -$367K | -2.18K | -0.71% | $168.54 | 306K | 18 Dec 2025 | Direct | F1, F8 |
| transaction | INSM | Common Stock | Sale | -$329K | -1.94K | -0.63% | $169.58 | 304K | 18 Dec 2025 | Direct | F1, F9 |
| transaction | INSM | Common Stock | Sale | -$61.6K | -362 | -0.12% | $170.26 | 304K | 18 Dec 2025 | Direct | F1, F10 |
| transaction | INSM | Common Stock | Sale | -$8.73K | -51 | -0.02% | $171.20 | 304K | 18 Dec 2025 | Direct | F1, F11 |
| holding | INSM | Common Stock | 234K | 18 Dec 2025 | By the Katie Procter Dynasty Trust | ||||||
| holding | INSM | Common Stock | 50.5K | 18 Dec 2025 | By the William Lewis Family Legacy Trust |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Underlying Class | Amount | Exercise Price | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | INSM | Stock Option (right to buy) | Options Exercise | $0 | -4.44K | -6.67% | $0.00 | 62.2K | 18 Dec 2025 | Common Stock | 4.44K | $17.16 | Direct | F1, F12 |
| transaction | INSM | Stock Option (right to buy) | Options Exercise | $0 | -6.26K | -6.67% | $0.00 | 87.6K | 18 Dec 2025 | Common Stock | 6.26K | $30.46 | Direct | F1, F12 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. |
| F2 | This is the weighted average sales price representing 350 shares sold at prices ranging from $161.72 to $162.69 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F3 | This is the weighted average sales price representing 1,465 shares sold at prices ranging from $162.72 to $163.62 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F4 | This is the weighted average sales price representing 447 shares sold at prices ranging from $163.75 to $164.73 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F5 | This is the weighted average sales price representing 697 shares sold at prices ranging from $164.83 to $165.67 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F6 | This is the weighted average sales price representing 1,783 shares sold at prices ranging from $166.00 to $166.99 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F7 | This is the weighted average sales price representing 1,431 shares sold at prices ranging from $167.00 to $167.95 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F8 | This is the weighted average sales price representing 2,175 shares sold at prices ranging from $168.01 to $169.00 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F9 | This is the weighted average sales price representing 1,938 shares sold at prices ranging from $169.01 to $170.00 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F10 | This is the weighted average sales price representing 362 shares sold at prices ranging from $170.02 to $170.91 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F11 | This is the weighted average sales price representing 51 shares sold at prices ranging from $171.09 to $171.35 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. |
| F12 | The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable. |