Christopher Grant Doughty - 15 Dec 2025 Form 4 Insider Report for CRESCENT BIOPHARMA, INC. (GLYC)

Role: Chief Business Officer
Signature: /s/ Barbara Bispham, as attorney-in-fact for Christopher Doughty
Issuer symbol: GLYC
Transactions as of: 15 Dec 2025
Net transactions value: $0
Form type: 4
Filing time: 17 Dec 2025, 16:47:45 UTC
Previous filing: 23 Jun 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Doughty Christopher Grant	Chief Business Officer	C/O CRESCENT BIOPHARMA, INC., 300 FIFTH AVENUE, WALTHAM	/s/ Barbara Bispham, as attorney-in-fact for Christopher Doughty	17 Dec 2025	0002074223

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	CBIO	Ordinary Shares	Award		+14,714	+37%		54,194	15 Dec 2025	Direct	F1
transaction	CBIO	Ordinary Shares	Award		+8,000	+15%		62,194	15 Dec 2025	Direct	F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	CBIO	Stock Option (Right to Buy)	Award	$0	+58,855		$0.000000	58,855	15 Dec 2025	Ordinary Shares	58,855	$13.21	Direct	F2

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Represents an award of Restricted Stock Units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Ordinary Shares. The RSUs shall vest in approximately equal three-month installments through the four-year anniversary of December 15, 2025, subject to the Reporting Person remaining continuously employed by or providing services to the Issuer or its subsidiaries from December 15, 2025 through each such vesting date.
F2	This Option represents a right to purchase shares of the Issuer's Ordinary Shares and vests with respect to 1/48th of the Option on each monthly anniversary of December 15, 2025, subject to the Reporting Person remaining continuously employed by or providing services to the Issuer or its subsidiaries from December 15, 2025 through each such vesting date.

Content

Represents an award of Restricted Stock Units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Ordinary Shares. The RSUs shall vest in approximately equal three-month installments through the four-year anniversary of December 15, 2025, subject to the Reporting Person remaining continuously employed by or providing services to the Issuer or its subsidiaries from December 15, 2025 through each such vesting date.

This Option represents a right to purchase shares of the Issuer's Ordinary Shares and vests with respect to 1/48th of the Option on each monthly anniversary of December 15, 2025, subject to the Reporting Person remaining continuously employed by or providing services to the Issuer or its subsidiaries from December 15, 2025 through each such vesting date.