Elizabeth A. Grammer - 21 Nov 2025 Form 4 Insider Report for ARDELYX, INC. (ARDX)

Role: Chief Legal and Administrative Officer
Signature: /s/ Elizabeth Grammer
Issuer symbol: ARDX
Transactions as of: 21 Nov 2025
Net transactions value: -$33,194
Form type: 4
Filing time: 25 Nov 2025, 16:44:48 UTC
Previous filing: 25 Aug 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
GRAMMER ELIZABETH A	Chief Legal and Administrative Officer	C/O ARDELYX, INC., 400 FIFTH AVENUE, SUITE 210, WALTHAM	/s/ Elizabeth Grammer	25 Nov 2025	0001213041

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	ARDX	Common Stock	Sale	$33,194	-5,995	-2%	$5.54	299,895	21 Nov 2025	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes.

Remarks:

Chief Legal and Administrative Officer